深圳市2010—2013年百日咳流行病学特征及抗体水平分析  

Antibody level and epidemiological character of pertussis in Shenzhen from 2010 to 2013

作　　者：刘刚[1] 卢紫燕[1] 林应和[1] 叶兆嘉[1] 

机构地区：[1]深圳市疾病预防控制中心免疫规划科,广东深圳518055

出　　处：《微生物学免疫学进展》2015年第4期40-43,共4页Progress In Microbiology and Immunology

摘　　要：目的通过对深圳市2010—2013年百日咳流行病学特征及健康人群百日咳抗体水平进行分析,为预防控制百日咳提供依据。方法采用描述性流行病学方法对深圳市2010—2013年法定传染病报告系统中的百日咳病例个案数据及2013年深圳市健康人群百日咳抗体水平进行分析。结果深圳市2010—2013年共报告百日咳病例176例,报告年均发病率为0.54/10万,其中2011年最高（0.72/10万）。报告病例中〈18月龄的占94.89%,有春夏季高发的现象,病例报告单位以深圳市儿童医院为主（92.05%）。2013年640份健康人群血清百日咳Ig G抗体阳性率为46.25%,其中≥20岁组的最高（70.67%）,4-5岁组的最低（25.45%）。各年龄组健康人群百日咳抗体水平阳性率差别有统计学意义（χ^2=19.01,P〈0.001）。结论深圳市近几年百日咳报告病例以18月龄以下儿童为主,除20岁以上成人外,其他年龄组人群百日咳抗体水平普遍不高,应针对适龄儿童制定针对性的百日咳防控策略。Objective To analyze the antibody level and epidemiological character of pertussis in Shenzhen from 2010 to2013,and to provide basis for pertussis prevention and control. Methods The individual data of pertussis cases from national notifiable disease reporting system from 2010 to 2013 and antibody level in 2013 in Shenzhen were analyzed by descriptive epidemiology,Bordetella pertussis gene analysis was carried out with duplex PCR and ELISA was used to detect specific pertussis toxin（ PT）-Ig G antibody. Results The average incidence of pertussis from 2010 to 2013 was 0. 2 case per 10^5,the highest incidence was in 2011（ 0. 72 case per 105）. 94. 89% cases were children less than 18 months old,most cases occurred in spring and summer season. The positive rate of the healthy population antibody against pertussis was46. 3%,the highest positive rate（ 70. 67%） occurred in the group of 20 years old above,the lowest positive rate（ 25. 45%） occurred in the group at the age of 4-5 years. The difference was statistically significant among age group（ χ^2= 19. 01,P〈0. 001）. Conclusion The children less than 18 months accounted for the most of the pertussis cases in Shenzhen in recent years. In addition to adults over the age of 20 years,the pertussis antibody level in other age groups is not high. It is very necessary to make targeted preventive and control strategy to school-age children.

关 键 词：百日咳 流行病学特征 抗体水平 分析 

分 类 号：R516.6[医药卫生—内科学]