病毒样颗粒及其疫苗研究  

The virus-like particles and its vaccine research

作　　者：童彦军 谢溱[1] 蒋琳[1] 

机构地区：[1]兰州生物制品研究所有限责任公司甘肃省疫苗工程技术研究中心,甘肃兰州730046

出　　处：《微生物学免疫学进展》2015年第4期69-74,共6页Progress In Microbiology and Immunology

摘　　要：随着传统疫苗的升级换代,疫苗的研制越来越多的借助于基因工程手段,其中病毒样颗粒(VLPs)成为了当今病毒性疫苗研究的热点,尤其对于不易在体外大规模培养的病毒,VLPs是研发其疫苗的突破口。关于VLPs及其疫苗的研究,从球状病毒的组装理论、病毒的VLPs组装、VLP疫苗设计和VLP疫苗等几个方面予以综述。With the upgrading of traditional vaccines,the vaccine development increasingly depends on the genetic engineering techniques,where the virus-like particles（ VLPs） has become a hot spot for today＇s vaccine research,especially for the viruses which could not be achieved at present by way of large-scale cultivation in vitro. VLPs has become a breakthrough in the development of such vaccines. This article will look at the following aspects for a summary,including the assembly theory of spherical virus,the VLPs assembly mechanism of several viruses,the VLP vaccine design and the VLP vaccines.

关 键 词：VLPS VLPs组装 VLP疫苗设计 VLP疫苗 

分 类 号：R392[医药卫生—免疫学]