rLj-RGD3对正常大鼠及角叉菜胶致尾混合血栓大鼠血液流变学的影响  

The hemorrheology effect of rLj-RGD3 in normal rats and carrageenan induced tail mixed thrombosis model rats

作　　者：吕莉[1,2] 王继红[1] 张艳[1] 邵钫钰 蒋隽舒 王跃[2] 肖蓉[1] 李庆伟[1] 

机构地区：[1]辽宁师范大学海洋生物功能基因与蛋白质组学研究所,辽宁大连116029 [2]大连医科大学药理教研室,辽宁大连116044

出　　处：《吉林医药学院学报》2015年第3期184-186,共3页Journal of Jilin Medical University

基　　金：国家高技术研究发展863计划资助项目(SS2014AA091602);国家自然科学基金(81202455);国家海洋公益项目(201305016-5)

摘　　要：目的研究r Lj-RGD3对正常大鼠及角叉菜胶致尾血栓模型大鼠的血液流变学的影响。方法测定给予不同剂量r Lj-RGD3后正常大鼠全血和血浆黏度,以评价r Lj-RGD3对正常大鼠血液流变学的影响;以角叉菜胶诱导大鼠尾部血栓模型,测定给予不同剂量r Lj-RGD3后血栓模型大鼠全血和血浆黏度,以评价r Lj-RGD3对血栓大鼠血液流变学的影响。结果与空白组相比,r Lj-RGD3对全血黏度及血浆黏度无明显影响;与血栓模型组相比,r Lj-RGD3呈剂量依赖性地降低全血比黏度浆和血浆比黏度的升高。结论 r Lj-RGD3可降低血栓模型大鼠血黏度,而对正常大鼠血液黏度无明显影响。Objective To study the hemorrheology effects of rLj-RGD3 in normal rats and carrageenan induced tail mixed thrombosis model rats. Methods The carrageenan induced rat tail mixed thrombosis model was established. Blood viscosity and plasma viscosity of normal rats and thrombosis model rats were determined after administered rLj-RGD3 in order to evaluate its hemorrheology effect in normal rats and thrombosis model rats. Results Compared with blank control group,rLj-RGD3 had no effect on blood viscosity and plasma viscosity in normal rats.In comparison with thrombosis model group,rats receiving i. p rLj-RGD3 showed a significant and dose-dependent inhibition on the increasing of blood viscosity and plasma viscosity. Conclusion rLj-RGD3 decreases the blood viscosity and plasma viscosity of thrombosis model rats,but has no effect on that of normal rats.

关 键 词：rLj-RGD3 角叉菜胶 血液流变学 全血黏度 血浆黏度 

分 类 号：R285[医药卫生—中药学]