幽门螺旋杆菌抗体检测在荨麻疹患者中的临床意义  

The clinical significance of Helicobacter pylori antibody detection in patients with urticaria

作　　者：邓玉奎[1] 王勇强[1] 邵勇[2] 

机构地区：[1]广东省深圳市北京大学深圳医院检验科,深圳518036 [2]广东省深圳市北京大学深圳医院皮肤科,广东深圳518036

出　　处：《广东医学院学报》2015年第2期229-231,共3页Journal of Guangdong Medical College

摘　　要：目的探讨幽门螺旋杆菌(Hp)感染与荨麻疹发生及发展的关系。方法采用胶体金免疫层析法检测120例荨麻疹患者(其中慢性荨麻疹75例,急性荨麻疹45例)及35例健康对照组的血浆Hp-Ig G抗体。结果慢性荨麻疹和急性荨麻疹患者与健康对照组的Hp-Ig G抗体阳性率分别为76.0%、42.2%、34.3%,其中现症感染阳性率分别为65.3%、37.8%、28.6%。慢性荨麻疹组的Hp-Ig G抗体阳性率和现症感染阳性率均明显高于急性荨麻疹组和健康对照组(P<0.01);急性荨麻疹患者与健康对照组之间则差异无统计学意义(P>0.05)。结论慢性荨麻疹患者的发病可能与Hp感染有关,对于病因不明的慢性荨麻疹患者应开展Hp的筛查,以及时了解其Hp感染的状况,这有助于临床及时调整诊治方案。Objective To explore the relationship between genesis and development of Helicobacter pylori（Hp） infection with urticaria. Methods The plasma Hp-Ig G antibody was detected by using colloidal gold immune chromatography in 120 cases of urticaria patients（45 cases of acute urticaria, 75 cases of chronic urticaria） and 35 cases of healthy controls. ResultsThe Hp-Ig G antibody positive rate with chronic urticaria,acute urticaria patients and healthy controls was 76.0%,42.2% and 34.3%. Newly emerging infection positive rate was 65.3%,37.8% and 28.6%. The Hp-Ig G antibody positive rate of chronic urticaria group and current infection was significantly higher than that of acute urticaria group and healthy controls（P〈0.01）. The differences was no statistical significance between acute urticaria patients and healthy controls（P〉0.05）. Conclusion The pathogenesis of chronic urticaria patients may be associated with Hp infection. Hp should be screened for unknown etiology of chronic urticaria patients and understand their conditions of Hp infection.which helps the clinical diagnosis and treatment and formulates plan in a timely manner.

关 键 词：幽门螺旋杆菌抗体 荨麻疹 免疫层析法 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]