加味八珍汤在骨折不愈合患者临床治疗中的应用  

The clinical effects of the patients with nonunion by Jiaweibazhen decoction

作　　者：高嵩[1] 杨光[1] 田书建[1] 罗建平[1] 

机构地区：[1]河南省人民医院骨科,郑州450003

出　　处：《中药药理与临床》2015年第3期145-147,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:探讨加味八珍汤在骨折不愈合患者临床治疗中的应用效果。方法:按照随机数字表法将82例关节骨折不愈合患者均分为实验组和对照组,分别给予加味八珍汤或元和接骨片,并配合局部金葡液注射治疗,比较治疗效果。结果:实验组患者治疗后关节各项症状体征评分均显著低于对照组,其中关节休息痛(0.35±0.54分vs 1.08±0.66分)、关节压痛(0.72±0.51分vs 1.14±0.67分)、关节肿胀(0.42±0.51分vs 1.02±0.58分)、关节功能(0.48±0.52分vs 1.02±0.42分)差异具有统计学意义;实验组患者治疗总有效率显著高于对照组,(87.80%vs 68.29%);实验组患者血清BMP-7、VEGF水平显著高于对照组(3.26±0.57 vs 2.35±0.38)、(212±30 vs 140±19);实验组胃肠反应发生率显著低于对照组(4.88%vs 17.07%)。结论:加味八珍汤能够有效促进骨折愈合,改善关节功能,提高BMP-7、VEGF水平,降低不良反应发生率,是治疗骨折不愈合的优选药物。Objective: To explore the clinical effects of the patients with nonunion by Jiaweibazhen Tang. Methods: 82 cases of patients with nonunion were randomly divided into experiment group and control group,they were treated by Jiaweibazhen Tang and Yuanhe bone pian combine with staphylococcal enterotoxin c injection respectively. The clinical effects were compared for the two groups. Results: The scores of symptoms and signs for the experiment group were lower than the control group,( 0. 35 ± 0. 54 vs 1. 08 ± 0. 66),( 0. 72 ± 0. 51 vs 1. 14 ± 0. 67),( 0. 42 ± 0. 51 vs 1. 02 ± 0. 58),( 0. 48 ± 0. 52 vs 1. 02 ± 0. 42)( P < 0. 05); The total effective rate for the experiment group were higher than the control group.( 87. 80% vs 68. 29%)( P < 0. 05); The rate of BMP-7 and VEGF for the experiment group were higher than the control group,( 3. 26 ± 0. 57 vs 2. 35 ± 0. 38),( 212. 06 ± 30. 27 vs 140. 22 ± 18. 62)( P < 0. 05); The rate of gastrointestinal reaction for the experiment group were lower than the control group,( 4. 88% vs 17. 07%)( P < 0. 05). Conclusion: It has good clinical effects of the patients with nonunion by Jiaweibazhen Tang,with small side effects,BMP-7 and VEGF,it is the preferred drug for treatment of fracture healing.

关 键 词：加味八珍汤 元和接骨片 金葡液 骨折不愈合 

分 类 号：R274.1[医药卫生—中医骨伤科学]