支气管哮喘与阻塞性睡眠呼吸暂停低通气综合征的相关研究  

Concurrence of Obstructive Sleep Apnea Hypopnea Syndrome with Asthma

作　　者：杜晶[1] 李林蔚[1] 祖萍[1] 邓燕[1] 何太灵[1] 袁玉茹[1] 梁斌苗[1] 

机构地区：[1]四川大学华西医院呼吸与危重症医学科,四川成都610041

出　　处：《中国呼吸与危重监护杂志》2015年第4期372-375,共4页Chinese Journal of Respiratory and Critical Care Medicine

基　　金：四川省科技厅支撑计划(编号:2014SZ0010)

摘　　要：目的分析支气管哮喘(简称哮喘)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的相关临床特点,探讨哮喘发生OSAHS的危险因素。方法收集2014年3月至2015年2月就诊于四川大学华西医院呼吸与危重症医学科门诊的哮喘患者,记录其临床资料及肺功能结果,根据柏林问卷结果将其分为OSAHS组与非OSAHS组,对组间资料进行比较,并对哮喘是否合并OSAHS的危险因素进行Logistic回归分析。结果共纳入64例哮喘患者,OSAHS的发生率为56.2%(36/64)。在OSAHS组中,体质指数(BMI)和过敏性鼻炎病史明显增高,而深吸气量、最大呼气中段流量和使第1秒钟用力呼气容积下降20%的累计激发剂量明显低于非OSAHS组。Logistic回归分析显示,增高的BMI与哮喘合并OSAHS的发生相关。结论哮喘合并OSAHS的发生率高,BMI是哮喘患者发生OSAHS的危险因素。Objective To evaluate the prevalence of obstructive sleep apnea hypopnea syndrome（ OSAHS） in patients with asthma,and explore the association of OSAHS with asthma. Methods Patients who were diagnosed as asthma between March 2014 and February 2015 were recruited in the study. They were categorized into an OSAHS group and a non-OSAHS group according to the Berlin questionnaire. The data of clinical characteristics and pulmonary function test were collected. Logistic regression analysis was performed to evaluate the factors associated with the incidence of OSAHS in asthma. Results A total of 64 patients with asthma were enrolled and 36 patients were complicated with OSAHS. The body mass index（ BMI）,allergic rhinitis history,inspiratory capacity,maximal mid-expiratory flow and provoking dose which make FEV1 reduce 20% were significantly different between two groups（ all P 0. 05）. Multivariate logistic regression analysis revealed that the increased BMI was an independent risk factor of OSAHS in patients with asthma. Conclusion The occurrence of OSAHS with asthma is very high,and BMI may be an important associated risk factor.

关 键 词：支气管哮喘 阻塞性睡眠呼吸暂停低通气综合征 危险因素 

分 类 号：R766[医药卫生—耳鼻咽喉科] R562.25[医药卫生—临床医学]