“铁扇癣痒平”喷雾膜剂的制备及质量评价  

Preparation and Evaluation of Tieshan Xuanyangping Spray Film

作　　者：苗孔颂[1] 王超君[2] 石镇东[2] 张尊祥[2] 

机构地区：[1]浙江工业大学,杭州310014 [2]南京军区杭州疗养院,杭州310014

出　　处：《海峡药学》2015年第7期14-15,共2页Strait Pharmaceutical Journal

基　　金：2011年浙江省中药现代化项目计划;第一批14号"三伏贴"温敏凝胶的制备及其在哮喘治疗中的应用;编号:20110312;2014年浙江省大学生科技创新活动计划暨新苗人才计划项目;编号:2014R403070

摘　　要：目的制备"铁扇癣痒平"喷雾膜剂,对其理化特性和使用效果进行初步评价。方法以泊洛沙姆407为基质,制备"铁扇癣痒平"喷雾膜剂。采用HPLC法测定含量;采用扩散池法测定皮内滞留量;采用家兔皮肤刺激性实验初步评价安全性。结果自制"铁扇癣痒平"喷雾膜剂外观良好;盐酸小檗碱含量91.4±0.6μg·g-1(n=3);其12h药物的皮内滞留量是酊剂的3.8倍;无明显皮肤刺激性。结论 "铁扇癣痒平"喷雾膜剂制备简单,使用方便,药物皮内滞留量高,且安全无刺激,具有良好的应用前景。OBJECTIVE To prepare and evaluate Tieshan Xuanyangping Spray Film （TX-SF）. METHODS TX-SF was prepared using Poloxamer 407 as matrix. The content of Berberine Hydrochloride was determined by HPLC, the drug retention in pig skin was investigated using Franz diffusion cell. , while the skin irritation was evalua- ted using Rabbits. RESULTS TX-SF was transparent and uniform. The content of Berberine Hydrochloride was 91.4 ± 0. 6μg · g -1 （ n = 3 ）. The drug retention of spray film was 2. 8 times more than that of tincture. No skin stimu- lus were observed. CONCLUSION TX-SF was easy to prepare, had high drug retention in skin and no skin irrita- tion. It had good application prospect.

关 键 词：铁扇癣痒平 喷雾膜剂 滞留量 

分 类 号：TQ460.4[化学工程—制药化工] R927.11[医药卫生—药学]