10%果糖注射液与10种药物配伍稳定性研究  

Stability Study of 10% Fructose Injection Mixed with 10 Kinds of Drugs

作　　者：黄攀豪[1] 赵翊畅 裴奇[1] 刘世坤[1] 

机构地区：[1]中南大学湘雅三医院药剂科,长沙410013 [2]湖南怀化市第三人民医院药剂科,怀化418000

出　　处：《海峡药学》2015年第7期17-19,共3页Strait Pharmaceutical Journal

摘　　要：目的探究果糖注射液与10种抗菌药物配伍的稳定性。方法观察不同时刻的配伍液外观、p H、不溶性微粒、紫外吸收光谱变化,果糖含量变化来确定临床常用的一些注射液与果糖注射液配伍时的稳定性。结果万古霉素、左氧氟沙星与10%果糖配伍后紫外吸收曲线、含量、p H值较其他药物变化明显,头孢呋辛等8种药物与果糖注射液配伍后稳定性及含量基本不变或变化不明显。结论万古霉素、左氧氟沙星不适宜与10%果糖注射液配伍;头孢呋辛等8种药物在与10%果糖注射液配伍时,有良好的稳定性,适宜与10%果糖注射液配伍。OBJECTIVE To investigate the compatibile stability of fructose injection mixed with 10 kinds of commonly used injectable drugs in clinical. METHODS Through numerous articles about fructose compatibility ex- periments and other drugs compatibility experiments, a variety of physical and chemical properties ： the appearance of the liquid in different times, pH, insoluble particles, UV absorption spectrum changes were observed, to determine the stability of fructose injection mixed with 10 commonly used injectable drugs in clinical. RESULTS Vancomycin and levofloxacin when mixed with 10% fructose injection present significant change of the UV absorption curve, content, and pH value compared to other drugs, while the other 8 drugs as cefuroxime basically unchanged or did not change significantly after compatibility in stability. CONCLUSION Vancomycin, and levofloxacin are considered unfit to 10% fructose injection. The other 8 drugs as cefuroxime can mix with 10% fructose injection injections keep nice sta- bility.

关 键 词：果糖 配伍 稳定性 

分 类 号：R927.11[医药卫生—药学]