盐酸纳洛酮在阿片类或乙醇类中毒患者中的临床应用及效果观察  

Naloxone hydrochloride in treatment of opioid or alcohol poisoning patients

作　　者：付帮林 匡冬梅 

机构地区：[1]胶州市人民医院,266300

出　　处：《国际医药卫生导报》2015年第15期2213-2216,共4页International Medicine and Health Guidance News

摘　　要：目的探究与分析盐酸纳洛酮在阿片类或乙醇类中毒患者中的I临床应用及效果。方法选取我院2012年12月至2014年12月收治的84例急性酒精中毒患者，采取随机数字表法分为对照1组与实验1组，各42例，比较两组酒精中毒症状消失时间、起效时间以及治疗有效率；同时选取我院2012年12月至2014年12月收治的60例阿片类药物吗啡过量使用导致中毒的患者，采取随机数字表法分为对照2组与实验2组，各30例，比较两组吗啡中毒症状消失时间、起效时间以及治疗有效率。结果对照1组的起效时间为（40．29±18．22）min，实验1组为（21．33±9．25）min，组间差异有统计学意义（t=3．98。P〈0．05）；对照1组症状消失时间为（80．29±28．32）min，实验1组为（40．33±14．23）min，组间差异有统计学意义（t=3．54，P〈0．05）。对照1组治疗总有效率为85．7％，实验1组为100．0％，实验1组有总效率比对照1组明显提高，组间差异有统计学意义（X^2=5．49，P〈0．05）。对照2组治疗总有效率为66．7％，实验2组为100．O％，实验2组总有效率比对照2组明显提高，组间差异有统计学意义（X^24．69，P〈0．05）。结论盐酸纳洛酮治疗急性酒精中毒或阿片类药物中毒，可有效控制中毒症状、缩短起效时间，有利于机体功能的恢复。Objective To explore and analyze the clinical application and effect of naloxone hydrochloride on opioid or alcohol poisoning patients. Methods The clinical data of 84 patients with acute alcoholism admitted into our hospital from December, 2012 to December, 2014 was retrospectively analyzed. According to random number table, they were divided into a control group 1 and an experimental group 1, 42 cases for each group. The alcohol poisoning symptoms disappearing time, time taking effect, and effectiveness of these two groups were compared. The clinical data of 60 patients with opioid poisoning caused by overusing morphine admitted into our hospital from December, 2012 to December, 2014 was retrospectively analyzed.According to random number table, they were divided into a control group 2 and an experimental group 2.The morphine poisoning symptoms disappearing time, time taking effect, and effectiveness of these two groups were compared. Results The time taking effect was （40.29±18.22） rain in the control group 1 and was （21.33±9.25） min in the experimental group l, with a statistical difference （t = 3.98, P 〈 0.05）; the symptoms disappearing time was （80.29±28.32） min in the control group 1 and was（40.33±14.23） min in the experimental group 1, with a statistical difference （t = 3.54, P 〈 0.05）. The the total effective rate was 85.7% in the control group 1 and was 100.0% in the experimental group 1, with a statistical difference （X^2 = 5.49, P 〈 0.05）. The total effective rate was 66.7% in the control group 2 and was 100.0% in the experimental group 2, with a statistical difference （X^2= 4.69, P 〈 0.05）. Conclusions Naloxone hydrochloride in the treatment of acute alcoholism or opioid drug poisoning can effectively control poisoning symptoms and shorten the time taking effect and is helpful for the recovery of body function.

关 键 词：阿片类中毒 乙醇类中毒 盐酸纳洛酮 

分 类 号：R979.3[医药卫生—药品]