25(OH)D、IL-6、IGF-1在2型糖尿病合并骨质疏松症患者血浆中的水平  

Content of 25(OH)D,IL-6,IGF-1 in patient with Type 2 Diabetes Mellitus complicating Osteoporosis

作　　者：阳琰[1] 高琳[1] 李庆钰[2] 晏永慧[1] 李显文[1] 陈其荣[1] 

机构地区：[1]遵义医学院附属医院内分泌科,贵州遵义563099 [2]遵义医学院临床技能实验室,贵州遵义563099

出　　处：《重庆医学》2015年第21期2898-2900,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81460168);贵州省科学技术基金资助项目[黔科合J字LKZ(2013)19号];遵义医学院博士启动基金资助项目[(2012)F-574];贵州省优秀科技教育人才省长专项资金项目[黔省专合字(2008)110号];贵州省科技合作项目[黔科合区域合(2010)7004号]

摘　　要：目的通过观察2型糖尿病(T2DM)合并骨质疏松患者血浆25羟维生素D[25(OH)D]、白细胞介素-6(IL-6)、胰岛素样生长因子(IGF-1)、血脂及胰岛素抵抗(IR)水平,探讨其相互之间的关系。方法将研究对象分为T2DM组120例、T2DM合并骨质疏松症(OS)组(T2DM+OS组)110例,糖耐量正常者(NGT组)115例,空腹抽血测定25(OH)D、IL-6、胰岛素样生长因子(IGF-1)、糖化血红蛋白(HbA1c)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDLC),并计算稳态模型胰岛素抵抗指数(HOMA-IR)进行比较分析。结果 T2DM组25(OH)D、IGF-1、HDL-C低于NGT组,而IL-6、HbA1c,TC,TG,LDL-C、HOMA-IR均高于NGT组,差异有统计学意义(P<0.05);T2DM+OS组25(OH)D、IGF-1、HDL-C低于NGT组,而IL-6、HbA1c,TC,TG,LDL-C、HOMA-IR均高于NGT组,差异有统计学意义(P<0.05);T2DM+OS组25(OH)D、IGF-1低于T2DM组,IL-6均高于T2DM组,差异有统计学意义(P<0.05),而HDL-C、HbA1c,TC,TG,LDL-C、HOMA-IR比较,差异无统计学意义(P>0.05)。结论血浆25(OH)D、IGF-1水平降低及IL-6水平升高可能是T2DM合并骨质疏松的高危因素之一。Objective To observe the level of 25-hydroxy vitamin D[25（OH）D],Interleukin,6 （IL-6）,Insulin-Like Growth Factor-l（IGF-1） ,blood lipid and insulin resistance（IR） in patients with type 2 diabetes mellitus（T2MD） and Osteoporosis. To in- vestigate the relationship of 25（OH）D3 with blood lipid and IR. Methods 120 patients with newly diagnosed T2DM group,ll0 pa- tients with type Z diabetes mellitus complicating Osteoporosis（T2DM ＋ os group）, 115 individuals with normal glucose tolerance （NGT group, as control） were enrolled. Fasting 25 （OH） I）, IL-6, IGF-1, HbA1 c, total cholesterol（TC）, triglyeeride（TG）, low densi- ty lipoprotein（LDL-C）,high density lipoprotein cholesterol（HDL-C） were determined. To compute HOMA-IR and to compare a- nalysis. Results The levels of 25（OH）D,IGF-1, HDL-C were more declined in T2DM group than those in NGT group （P〈0.05）. The levels of IL-6, HbAlc,TC, TG, LDL-C, HOMA-IR were significantly higher in T2DM group than those in NGT group（P〈 0.05）. The levels of 25（OH）D,IGF-1, HDL-C were more decl^ned in T2DM ＋os group than those in NGT group （P〈0.05）. The levels of IL-6, HbAlc, TC,TG,LDL-C, HOMA-IR were significantly higher in T2DM -}- os group than those in NGT group（P〈 0.05）. The levels of 25（OH）D,IGF＇l were more declined in T2DM q-OS group than those in T2DM group （P〈0.05）. The levels of IL-6 were significantly higher in T2DM -kOS group than those in T2DM group（P〈0.05）;the levels of HDL-C, HbAlc, TC, TG,LDL：C,HOMA-IR have no difference comparing T2DM ＋OS group and T2DM group（P〉0.05）, Conclusion The low levels of 25（OH）D,IGF-1 and high levels of IL-6 is a high risk of type 2 diabetes metlitus complicating osteoporosis.

关 键 词：白细胞介素6 胰岛素样生长因子Ⅰ 糖尿病 2型 骨质疏松 25羟维生素D 

分 类 号：R587.2[医药卫生—内分泌] R580[医药卫生—内科学]