调脂药物在非酒精性脂肪性肝病中的应用  

Application of lipid- regulating drugs in non- alcoholic fatty liver disease

作　　者：崔瑞冰[1] 阎明[1] 

机构地区：[1]山东大学齐鲁医院,济南250012

出　　处：《临床肝胆病杂志》2015年第7期1038-1041,共4页Journal of Clinical Hepatology

摘　　要：非酒精性脂肪性肝病(NAFLD)是以弥漫性肝细胞脂肪变性为主要特征,且患者无过量饮酒史的临床综合征,是导致肝功能异常及慢性肝脏疾病最常见的病因之一。调脂药物一方面可以降低血脂,对肝脏沉积有治疗作用;另一方面又可促进脂质在肝内的积累,从而加重肝损伤。尽管NAFLD的确切病因及发病机制尚未完全确定,鉴于NAFLD的病理基础是肝细胞的脂肪变性,因此调脂药物能否用于治疗NAFLD一直是人们争论的问题。简述了调脂药物对NAFLD、非酒精性脂肪性肝炎及肝硬化的影响。Non- alcoholic fatty liver disease（ NAFLD） is a clinical syndrome which is characterized by diffuse fatty degeneration of hepatocytes without excessive use of alcohol,and it is one of the most common causes of abnormal liver function and chronic liver disease. Although the etiology and pathogenesis of NAFLD have not been well defined,the pathological basis of NAFLD is fatty degeneration of hepatocytes. On the one hand,the lipid- regulating drugs can reduce blood lipids to decrease liver fat deposition; on the other hand,they can promote lipid accumulation in the liver to increase liver injury. So there is still controversy that if the lipid- regulating drugs can be used for treating NAFLD. In this paper,the application and progression of four lipid- regulating drugs,statins,fibrates,probucol,and ezetimibe,in NAFLD are briefly described.

关 键 词：脂肪肝 调脂药物 

分 类 号：R575[医药卫生—消化系统]