调节肠道菌群在中医药治疗非酒精性脂肪性肝病中的作用和意义  

Role of gut microbiota regulation in traditional Chinese medicine treatment of non- alcoholic fatty liver disease

作　　者：田华捷 冯琴[1] 胡义扬[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海中医药大学肝病研究所,上海201203

出　　处：《临床肝胆病杂志》2015年第7期1042-1045,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81173404);上海市科委科技支撑项目(13401900303);上海高校中医内科学E-研究院和国家中医药管理局中医肝胆病重点学科项目资助

摘　　要：根据近年来研究发现肠道菌群在非酒精性脂肪性肝病(NAFLD)的发病机制中具有重要作用,系统阐述了在NAFLD与肠源性内毒素血症、短链脂肪酸、胆汁酸代谢、内源性乙醇的关系基础上,结合对中药调节肠道菌群与治疗NAFLD作用关系的研究进展,提出中药靶向调节肠道菌群,不仅是中医药临床治疗实践的现代诠释,更重要的是有可能成为NAFLD治疗的一种新策略。Based on recent studies which have shown that gut microbiota plays an important role in the pathogenesis of non- alcoholic fatty liver disease（ NAFLD）,the article elaborates on the relationship of NAFLD with intestinal endotoxemia,short- chain fatty acids,bile acid metabolism,and endogenous ethanol. By illustrating the author＇s research progress in the relationship between traditional Chinese medicine（ TCM） regulation of gut microbiota and NAFLD treatment,the article proposes that this approach is not only a clinical practice of TCM in the modern era,it may also become a new strategy in the treatment of NAFLD.

关 键 词：脂肪肝 肠杆菌属 中医药 治疗 

分 类 号：R259[医药卫生—中西医结合]