HBV细胞模型研究进展  

Research advances in cell models of hepatitis B virus

作　　者：吴疆[1] 周振华[1] 孙学华[1] 朱晓骏[1] 李曼[1] 张鑫[1] 高月求[1] 

机构地区：[1]上海中医药大学附属曙光医院肝病科,上海市中医临床重点实验室,上海201203

出　　处：《临床肝胆病杂志》2015年第7期1168-1172,共5页Journal of Clinical Hepatology

基　　金：国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2012ZX10005004-002;2012ZX-10005010-002-003);教育部博士点专项基金(20123107110003);上海市科委科技支撑项目(13401902900);上海市中医药事业发展三年行动计划项目(ZYSNXD-CC-ZDYJ015/048);上海市科委扬帆计划(14YF1411600);上海中医药大学预算内项目(2013JW40)

摘　　要：HBV感染已成为肝癌发病的最主要原因,建立一系列HBV细胞模型为研究HBV的致病机理和治疗奠定了良好的基础。介绍了以HBV转染和感染为主的单一种类细胞培养模型、多种细胞共培养模型以及其他动物模型,探讨HBV感染细胞模型的建立方法及其病毒学特点,为科学阐释中医药防治慢性乙型肝炎的优势作用环节提供可靠的模型依据。Hepatitis B virus（ HBV） infection has become the main cause of hepatocellular carcinoma. A series of cell models for HBV infection are established to lay a good foundation for the research on the pathogenesis and treatment of HBV. In this review,we summarize culture models for a single type of cells,co- culture models for multiple types of cells,and other animal models,which are mainly for HBV transfection and infection. We also discuss the methods of cell model construction for HBV infection and their virological characteristics. It provides reliable evidence of models for scientific interpretation of advantages of traditional Chinese medicine in the prevention and treatment of chronic hepatitis B.

关 键 词：肝炎病毒 乙型 细胞培养技术 综述 

分 类 号：R512.62[医药卫生—内科学]