再生障碍性贫血患者铜/锌比对淋巴细胞亚群的影响  

Effect of Copper/Zinc Ratio on Lymphocyte Subsets in Aplastic Anemia Patients

作　　者：高铁铭 付建珠 赵亚玲[2,3] 王亚丽[3] 成志勇[3] 张霞[1] 曾志祥[1] 王丽莉[1] 

机构地区：[1]定州市人民医院内科,河北定州073000 [2]承德医学院,河北承德067000 [3]保定市第一医院血液内科,河北保定071000

出　　处：《南昌大学学报（医学版）》2015年第3期44-47,共4页Journal of Nanchang University：Medical Sciences

基　　金：保定市科技计划(13ZF092)

摘　　要：目的研究血清铜、锌及铜/锌比值在再生障碍性贫血中的水平变化,以及对外周血T淋巴细胞亚群的影响。方法选择50例再生障碍性贫血患者(初治再障组),经过正规治疗,可随访患者42例[根据治疗方法不同分为标准治疗组(22例,应用雄激素+免疫抑制剂治疗)和葡萄糖酸锌治疗组(20例,在标准治疗组基础上加用萄糖酸锌口服液治疗)]。选择同期40例健康正常人为正常对照组。采用原子吸收分光光度法测定血清铜、锌及铜/锌比值,流式细胞仪检测患者外周血T淋巴细胞亚群。结果初治再障组患者血清铜含量及铜/锌比值均高于正常对照组,而锌含量明显低于正常对照组(均P<0.01)。再生障碍性贫血患者铜/锌比值与CD4+/CD8+呈负相关(r=―0.45,P=0.005)。治疗后葡萄糖酸锌治疗组患者CD4+/CD8+比值恢复好于标准治疗组(P=0.000)。结论铜/锌比值与T淋巴细胞亚群失调共同参与再生障碍性贫血的发病及转归。Objective To study the changes in serum copper and zinc levels and copper/zinc ra-tio in aplastic anemia,and to investigate their effect on T lymphocyte subsets.Methods Atomic absorption spectrophotometry was used to detect serum copper and zinc levels and copper/zinc ra-tio and flow cytometry was used to measure T lymphocyte subsets in peripheral blood in 50 aplas-tic anemia patients （initial treatment group）and 40 healthy subjects （control group）.According to different treatments,42 patients who receive follow-up were divided into two groups：standard treatment group （androgen＋ immunosuppressants,n = 22）and zinc gluconate treatment group （androgen＋ immunosuppressants ＋ zinc gluconate,n = 20 ）.Results Compared with control group,serum copper levels and copper/zinc ratio increased and serum zinc levels decreased in ini-tial treatment group （P 〈 0.01 ）.The copper/zinc ratio was negatively correlated with CD4 ＋/CD8＋ （r=-0.45,P =0.005）.Compared standard treatment group,zinc gluconate treatment pro-moted the recovery of CD4＋/CD8＋ ratio （P =0.000）.Conclusion Both copper/zinc ratio and T lymphocyte subset imbalance are involved in the onset and prognosis of aplastic anemia.

关 键 词：再生障碍性贫血 铜/锌比值 淋巴细胞亚群 

分 类 号：R556.5[医药卫生—血液循环系统疾病]