老年代谢综合征患者血清C反应蛋白、尿酸及血脂的变化  

Change of serum C reactive protein,uric acid and blood lipid in elderly patients with metabolic syndrome

作　　者：方芳[1] 扈友庄[1] 谈山峰[1] 金海霞[1] 郑冬杏[1] 李玉丽[1] 王俊贤[1] 

机构地区：[1]广东医学院附属医院老年病科,广东湛江524001

出　　处：《包头医学院学报》2015年第7期20-22,共3页Journal of Baotou Medical College

基　　金：湛江市科技攻关项目(2013B01129)

摘　　要：目的:探讨老年代谢综合征患者体内血清C反应蛋白(C-reactive protein,CRP)、尿酸及血脂水平的变化,以及C反应蛋白与胰岛素抵抗、血尿酸、血脂的相互关系。方法:研究对象为老年代谢综合征组100例及正常对照组30例。用免疫透光比浊法测定法检测血清C反应蛋白水平,同时测量身高、体重、腰围、空腹胰岛素、血糖、血脂、血尿酸等。老年代谢综合征组以BMI为28为界值,分为代谢综合征肥胖组和非肥胖组,对其进行方差分析和相关分析。结果:(1)老年代谢综合征肥胖组、非肥胖组与正常对照组的空腹血清CRP值分别为:(10.46±0.78)mg/L、(8.75±1.32)mg/L、(5.26±0.89)mg/L,三组之间比较差异均具有统计学意义(P<0.05)。(2)MS肥胖组、MS非肥胖组及对照组的血尿酸值分别为(362.88±71.45)μmol/L、(348.89±92.21)μmol/L、(222.75±51.04)μmol/L,三组之间比较差异均具有统计学意义(P<0.05)。(3)相关性分析:CRP与HOMA-IR,BMI,TG,TC,LDL,UA呈正相关,与HDL呈负相关(P<0.05)。结论:C反应蛋白与胰岛素抵抗、血尿酸、血脂相关,而代谢综合征的基础是胰岛素抵抗,因此如何改善胰岛素抵抗,降低血尿酸、改善血脂将成为代谢综合征药物治疗的方向。Objective： To explore the changes of blood serum C-reactive protein（ CRP） 、uric acid（ UA） and blood lipid in elderly patients with metabolic syndrome（ MS）,and then analyze the interrelation between CRP、insulin resistance、blood UA and blood lipid. Methods： The study subjects were 100 elderly patients with MS and 30 cases of normal control group. Fasting blood serum CRP was measured by using the method of the determination of immune transmission-turbidimetry,with the height,weight,waist,fasting insulin,glucose,blood lipid,blood UA and so on measured as well. The elderly subjects with MS were divided into the obesity group with MS and non-obesity group at the 28 point of BMI,with variance analysis and correlation analysis conducted. Results：（ 1） The fasting serum CRP concentration in the obesity group with elderly MS,the non-obesity group and the normal control group was（ 10. 46 ± 0. 78 mg / L） 、（ 8. 75 ± 1. 32 mg / L） 、（ 5. 26 ± 0. 89） mg / L,respectively. The difference between every two groups was statistically significant（ P〈0. 05）.（ 2） Serum UA concentration in the elderly obesity group with MS,the non-obesity group with MS and the normal control group was（ 362. 88 ± 71. 45μmol / L,（ 348. 89 ± 92. 21μmol / L） 、（ 222. 75 ± 51. 04） μmol /L,respectively. The difference between every two groups was statistically significant（ P〈0. 05）.（ 3） Correlation analysis showed that CRP was positively correlated with HOMA-IR、BMI、TG、TC、LDL、UA and had negative correlation with HDL（ P〈0. 05）. Conclusion： CRP is correlated with insulin resistance、blood UA and blood lipid. The basis of the metabolic syndrome is insulin resistance,so how to improve insulin resistance,decreasing the blood uric acid,and improving blood lipid will become the direction of drug treatment of metabolism syndrome.

关 键 词：C反应蛋白 代谢综合征 胰岛素抵抗 血脂 血尿酸 

分 类 号：R589[医药卫生—内分泌]