不同联合用药方法预防妇科腹腔镜术后恶心呕吐效果比较  

THE ANTI-POSTOPERATIVE NAUSEA AND VOMITING EFFECT OF DIFFERENT CO-ADMINISTRATION METHODS IN GYNECOLOGICAL LAPAROSCOPY

作　　者：刘淑丽 郑丹华[2] 张燕燕 李玺[2] 

机构地区：[1]汕头市朝阳区大峰医院,广东汕头515154 [2]中山大学附属第三医院,广东广州510630

出　　处：《现代医院》2015年第8期39-40,共2页Modern Hospitals

基　　金：广东省科技计划资助项目(编号:2012B061700065)

摘　　要：目的观察三种联合用药方法预防妇科腹腔镜手术后恶心呕吐效果。方法择期妇科腹腔镜手术患者180例,随机分为A、B、C三组,每组60例,分别在手术结束前静脉注射托烷司琼2 mg+胃复安10 mg(A组)、托烷司琼2 mg+地塞米松10 mg(B组)、胃复安10 mg+地塞米松10 mg(C组),观察患者术后24 h恶心呕吐发生率。结果三组术后24 h恶心呕吐总发生率分别为49%、38.4%、43.7%,各组间比较差异无统计学意义(均p>0.05),B组和C组Ⅳ级恶心呕吐发生率明显小于A组(均p<0.05),C组Ⅲ级恶心呕吐发生率明显小于B组(p<0.05)。结论胃复安复合地塞米松预防妇科腹腔镜术后Ⅲ级以上恶心呕吐效果优于胃复安复合托烷司琼及地塞米松复合托烷司琼。Objective To study the effects of three co-administration methods on preventing postoperative nausea and vomi-ting in gynecological laparoscopy.Methods 180 gynecological laparoscopy patients under general anesthesia were randomly divided into three groups group A, B, and C.Each group have 60 cases, and was intravenously given tropisetron 2 mg combined with pasper-tin 10 mg, tropisetron 2 mg combined with dexamethasone 10 mg, paspertin 10 mg combined with dexamethasone 10mg respectively at the end of operation.PONV incidence within 24 hours was recorded.Results PONV incidence in the three groups were 49%, 38.4%, 43.7% respectively and there is no significantly difference between the three groups （p〉0.05）.Compared with group A, the PONV incidence of gradeⅣ in group B and C are lower （p〈0.05） and the PONV incidence of grade Ⅲ in group C is lower than group B （p〈0.05）.Conclusion Paspertin combined with dexamethasone is better than paspertin combined with tropisetron or dex-amethasone combined with tropisetron in reducing PONV incidence over grade Ⅲ in gynecological laparoscopy.

关 键 词：托烷司琼 胃复安 地塞米松 术后恶心呕吐 

分 类 号：R619.9[医药卫生—外科学]