乌司他丁对行食管癌根治术患者肺损伤的保护作用分析  

Analysis of protective effect of ulinastatin on pulmonary injury during radical resection of esophageal carcinoma

作　　者：张怀忠[1] 吴旭辉[1] 吴功志[1] 彭丛兄[1] 彭旭阳[1] 

机构地区：[1]丽水市人民医院胸外科,浙江丽水323000

出　　处：《实用药物与临床》2015年第7期788-790,共3页Practical Pharmacy and Clinical Remedies

基　　金：卫生行业科研专项项目(201302016)

摘　　要：目的研究乌司他丁对食管癌根治术患者肺损伤的保护作用。方法选择2012年10月至2014年10月于我院行食管癌根治术患者80例,以数字表法随机分为观察组及对照组,每组40例。观察组患者应用乌司他丁,对照组患者使用等量生理盐水。检测两组患者肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-8及IL-10等炎症因子水平,同时记录患者的平均气道压(Pmean)及氧合指数(Pa O2/Fi O2)。结果治疗后,两组的TNF-α、IL-6、IL-8、IL-10升高,与治疗前比较差异均有统计学意义(P<0.05);与对照组比较,观察组TNF-α、IL-6、IL-8较低,IL-10较高,差异有统计学意义(P<0.05)。治疗后,观察组的Pmean降低,Pa O2/Fi O2显著升高,两组比较,差异有统计学意义(P<0.05)。结论乌司他丁对于食管癌根治术后患者的肺部具有重要的保护作用,其保护机制与全身炎性反应的减少存在一定联系。Objective To study the protective effect of ulinastatin on pulmonary injury during radical resection of esophageal carcinoma. Methods Eighty patients undergoing radical resection of esophageal carcinoma from October2012 to October 2014 in our hospital w ere chosen and randomly divided into observation group and control group,40 cases in each group. Patients in observation group w ere given ulinastatin,and the patients in control group received the same amount of normal saline. The serum levels of inflammatory factors w ere compared betw een the tw o groups before and after treatment as w ell as the level of lung function. Results After treatment,the levels of TNF-α,IL-6,IL-8 and IL-10 levels of the tw o groups increased significantly（ P〈0. 05）. Compared w ith control group,the levels of TNF-α,IL-6,IL-8 and Pmeanw ere low er and the IL-10,Pa O2/ Fi O2 w as higher,there w ere significant differences betw een the tw o groups（ P〈0. 05）. Conclusion Ulinastatin has protective effect on the lung injury after radical resection of esophageal carcinoma,and the mechanism may be related to the decrease of systemic inflammatory response.

关 键 词：乌司他丁 食管癌根治术 肺损伤 保护作用 

分 类 号：R735.1[医药卫生—肿瘤]