氯诺昔康与盐酸昂丹司琼在静脉镇痛泵中的配伍相容性研究  

Physico-chemical stability of lornoxicam with ondansetron hydrochloride in patient controlled analgesia solution

作　　者：陆连英[1] 陈富超[1] 徐传念 杨兴明[1] 时晓亚[1] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008

出　　处：《实用药物与临床》2015年第7期826-829,共4页Practical Pharmacy and Clinical Remedies

基　　金：十堰市科学技术研究与开发计划项目(2010st45)

摘　　要：目的考察氯诺昔康与盐酸昂丹司琼在0.9%氯化钠注射液中的配伍相容性。方法采用HPLC法测定配伍液中氯诺昔康与盐酸昂丹司琼的含量,分别于0、2、4、8、24、48、72 h时间点观察配伍液是否出现沉淀、浑浊及颜色变化,同时测定配伍液p H值变化。结果配伍液中氯诺昔康含量未见明显变化,盐酸昂丹司琼含量随时间延长逐渐降低,在2 h时含量低于90%,且出现少量絮状沉淀。结论在室温条件下,氯诺昔康与盐酸昂丹司琼在0.9%氯化钠注射液中不稳定,临床不宜混合用于术后镇痛。Objective To study the physico-chemical stability of lornoxicam with ondansetron hydrochloride in 0. 9% sodium chloride injection. Methods The contents of lornoxicam and ondansetron hydrochloride in mixture solution w ere determined by HPLC. Solutions w ere visually inspected for precipitation,cloudiness,and discoloration at0,2,4,8,24,48 and 72 h after compatibility. The changes in p H value of the mixture w ere recorded. Results No significant difference w as found in the p H value and contents of lornoxicam,but the contents of ondansetron hydrochloride declined（ 90%） w ith appearance of precipitation at the time point of 2 h. Conclusion The mixture of lornoxicam w ith ondansetron hydrochloride in 0. 9% sodium chloride injection is unstable,and the clinical application for patient controlled analgesia should be avoided.

关 键 词：氯诺昔康 盐酸昂丹司琼 配伍 稳定性 高效液相色谱法 

分 类 号：R969.2[医药卫生—药理学]