FOX基因与白血病相关性研究进展  

Relationship between FOX family genes and leukemia

作　　者：伊英杰(综述)[1] 贾秀红(审校)[1] 

机构地区：[1]滨州医学院附属医院儿科,256603

出　　处：《国际儿科学杂志》2015年第4期397-399,共3页International Journal of Pediatrics

基　　金：山东省教育厅科学技术发展计划（2010GSFl0264）

摘　　要：FOX基因家族编码一类多元化转录因子，其中FOXO3a、FOXM1、FOXP3是FOX基因家族成员，这三种基因均在白血病中异常表达。 FOXO3a以磷酸化失活状态表达于白血病细胞质，丧失抗白血病功能；FOXM1是一个致癌基因，高表达于髓系白血病细胞；FOXP3在白血病细胞的表达具有多样性，主要高表达于T细胞白血病细胞。这三种基因的异常表达与白血病的发生发展、治疗、耐药及预后密切相关。FOX genes code transcription factors. FOXO3a,FOXM1,FOXP3 are members of FOX genes family,which are associated with leukemia. Phosphorylated FOXO3a which loses the function of suppressing leu-kemia is inactive. Phosphorylated FOXO3a expresses in leukemic cell cytoplasm. FOXM1 is an oncogenesis tran-scription factor. FOXM1 highly expresses in myeloid leukemic cells. Expression of FOXP3 in leukemic cells has diversity. FOXP3 mainly expresses in T cell leukemic cells. These genes abrrant expressions play a key role in leukemia pathogenesis,development,therapy,drug resistance and prognosis.

关 键 词：白血病 FOXP3a FOXM1 FOXP3 

分 类 号：R979.1[医药卫生—药品]