超微加味丹参饮对原发性高脂血症合并颈动脉粥样硬化患者血清VEGF、MMP-9的影响  

Effects of Ultramicro-Jiawei Danshen Yin on Serum VEGF、MMP-9 of Patients with Primary Hyperlipidemia and Carotid Atherosclerotic

作　　者：潘小平[1] 黄政德[2] 杨伟峰[3] 胡剑卓[1] 左和宁[4] 刘凌云[4] 陈辉[1] 

机构地区：[1]湖南中医药大学第二附属医院,湖南长沙410005 [2]湖南中医药大学,湖南长沙410208 [3]广州空军司令部医院,广东广州510071 [4]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中医药导报》2015年第16期21-24,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(81373576);湖南省中医药管理局重点项目(201304);湖南省教育厅优秀青年项目(4B136)

摘　　要：目的:观察超微加味丹参饮治疗原发性高脂血症合并颈动脉粥样硬化斑块的临床疗效。方法:60例患者随机分为治疗组(超微加味丹参饮)和对照组(辛伐他汀+阿司匹林),连续治疗6月。观察治疗前后血脂、超敏C反应蛋白(hs-CRP)、血管内皮细胞生长因子(VEGF)、基质金属蛋白酶9(MMP-9)、颈动脉内膜中层厚度(IMT)、颈动脉内膜斑块面积的变化并比较不良反应。结果:经治疗两组血清血脂、hs-CRP、VEGF、MMP-9水平及颈动脉IMT及内膜斑块面积均有明显改善(P<0.05或P<0.01);与对照组比较,超微加味丹参饮在降低血清TC、APOB及VEGF、MMP-9水平,升高HDLC及降低颈动脉IMT,减少颈动脉内膜斑块面积方面疗效更优,两者差异有统计学意义(P<0.05),而对hs-CRP的作用相当(P>0.05)。两组均未出现不良反应及毒副作用。结论:超微加味丹参饮通过调节血脂、降低hs-CRP抑制炎症,下调血清VEGF、MMP-9稳定斑块,降低IMT值,减少颈动脉内膜斑块面积发挥抗AS作用,对原发性高脂血症合并颈动脉粥样硬化斑块有较好的疗效,且临床未见明显毒副作用,优于常规西药治疗。Objective： To observe the effects of Jiawei Danshen Yin （JWDSY, 加味丹参饮） on patients with primary hy- perlipidemia and carotid atherosclerotic plaques. Method： The 60 patients with primary hyperlipidemia and carotid atherosclerot- ic plaques were randomly divided into treatment group （Uhramicro-Jiawei Danshen Yin） and control group （simvastatin plus as- pirin）, to observe the changes of serum lipid, hypersensitive c-reactive protein （hs-CRP）, Vascular endothelial growth fac- tor（VEGF）, Matrix metalloproteinase9 （MMP-9）, carotid intima-media thickness （IMT）, carotid intimal plaque and the adverse reactions. The treatment lasted for 6 months. Results： The levels of lipid, hs-CRP, VEGF, MMP-9, carotid IMT value and plaque area were obviously improved in both groups after treatment （P〈0.05 or P〈O.01）. The effects of the treatment group was better than the control group in reducing the levels of TC, APOB, VEGF, MMP-9 and carotid IMT, elevating the level of HDLC, and decreasing the plaque area, the difference has statistical significance （P〈0.05）. But both groups showed similar effi- cacy in hs-CRP （P〉0.05）. There was no adverse reaction and side effect during the treatment in both groups. Conclusions： U1- tramicro-Jiawei Danshen Yin is effective for primary hyperlipidemia and carotid atherosclerotic plaques without obvious adverse reaction and side effect. It＇s more effective than routine western medicine, and it＇s mechanism of anti-atherosclerosis was cor- related with the function of regulating lipid, reducing the level of hs-CRP and anti-inflammation, lowering level of serum VEGF, MMP-9, stabilizing plaques, decreasing IMT value, carotid intimal plaque area.

关 键 词：加味丹参饮 超微饮片 颈动脉粥样硬化斑块 颈动脉内膜中层厚度 血管内皮细胞生长因子 基质金属蛋白 酶9 超敏C反应蛋白 高脂血症 

分 类 号：R285.5[医药卫生—中药学]