免疫固定电泳和骨髓细胞形态学检查在多发性骨髓瘤临床分期中的价值比较  

Significance comparison of immunofixation electrophoresis and bone marrow cell morphology examination in clinical typing of multiple myeloma

作　　者：崇慧峰[1] 孙芸[1] 王传发[1] 汪亚勤[1] 曹春鸾[1] 周萍[1] 

机构地区：[1]铜陵市人民医院检验科,安徽铜陵244000

出　　处：《检验医学》2015年第7期720-722,共3页Laboratory Medicine

摘　　要：目的探讨免疫固定电泳（IFE）和骨髓细胞形态学检查在多发性骨髓瘤（MM）临床分期中的价值。方法按照International Staging System（ISS）分期标准将89例MM患者分为Ⅰ~Ⅲ期,其中ISSⅠ期18例、ISSⅡ期23例、ISSⅢ期48例。比较各期患者间血清IFE结果和骨髓细胞形态学检验结果的差异,并分析各指标与ISS分期的关系。结果 ISS各期中免疫球蛋白（Ig）分型均以Ig G型为主（占50%以上）。ISSⅡ、Ⅲ期的M蛋白阳性率和骨髓瘤细胞比例均高于ISSⅠ期（P均〈0.05）;ISSⅢ期M蛋白阳性率和总体阳性率均明显高于骨髓细胞形态学（骨髓瘤细胞比例≥10%为标准）（P〈0.05）;ISS各期之间M蛋白和骨髓细胞形态学阳性率差异均有统计学意义（P均〈0.05）。结论 MM患者随着ISS分期的增高,其M蛋白阳性率和骨髓瘤细胞比例有增高趋势。Objective To investigate the significance of immunofixation electrophoresis（ IFE） and bone marrow cell morphology examination in clinical typing of multiple myeloma（ MM）. Methods According to the staging criterion of International Staging System（ ISS）,MM patients were classified into stageⅠ（ 18 cases）,stage Ⅱ（ 23 cases） and stage Ⅲ（ 48 cases）. The results of serum IFE and bone marrow cell morphology examination in all patients were compared,and the correlation between all indicators and ISS staging was analyzed. Results Immunoglobulin（ Ig） G was the main type among the clinical stages. The positive rates of M protein and myeloma cell percentage in stage Ⅱ andⅢ were higher than those in stageⅠ（ P〈0. 05）. The positive rates of M protein in stage Ⅲ and overall positive rate were significantly higher than those of bone marrow cell morphology（ myeloma cell percentage ≥10% as standard）（ P〈0. 05）. The difference of M protein and bone marrow cell morphology positive rates between the clinical stages was statistically significant（ P〈0. 05）. Conclusions The positive rate of M protein and myeloma cells percentage have an increasing trend with the increase of clinical ISS stage in MM patients.

关 键 词：多发性骨髓瘤 临床分期 免疫固定电泳 骨髓瘤细胞 

分 类 号：R446.1[医药卫生—诊断学]