Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects  

作　　者：Zhen Zhang Tao Sun Jian-guo Niu Zhen-quan He Yang Liu Feng Wang 

机构地区：[1]Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University [2]Department of Neurosurgery, General Hospital of Ningxia Medical University

出　　处：《Neural Regeneration Research》2015年第7期1125-1133,共9页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81460208;the Ningxia Natural Science Foundation of China,No.NZ13163

摘　　要：Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in epilepsy models. Prior to model establishment, mice were intragastrically administered 25 mg/kg amentoflavone for 3 consecutive days. Amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons. Results suggested that amentoflavone protected hippocampal neurons in epilepsy mice via anti-inflammation, antioxidation, and antiapoptosis, and then effectively prevented the occurrence of seizures.Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in epilepsy models. Prior to model establishment, mice were intragastrically administered 25 mg/kg amentoflavone for 3 consecutive days. Amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons. Results suggested that amentoflavone protected hippocampal neurons in epilepsy mice via anti-inflammation, antioxidation, and antiapoptosis, and then effectively prevented the occurrence of seizures.

关 键 词：nerve regeneration brain injury epilepsy neuroprotection apoptosis nuclear factor-κB brain inflammation interleukin-6 interleukin-1 beta inducible nitric oxide synthase nitric oxide prostaglandin E2 NSFC grant neural regeneration 

分 类 号：R285[医药卫生—中药学]