丁苯酞治疗2型糖尿病轻度认知障碍疗效观察  

Clinical Effect of Butylphthalide Soft Capsules in the Treatment of Type 2 Diabetic Patients with Mild Cognitive Impairment

作　　者：王传刘[1] 林海燕[1] 万金星[2] 

机构地区：[1]衢州市人民医院神经内科,324000 [2]衢州市人民医院内分泌科,324000

出　　处：《医学研究杂志》2015年第7期75-77,共3页Journal of Medical Research

基　　金：浙江省医药卫生科学研究基金计划项目(2008A164)

摘　　要：目的探讨丁苯酞胶囊治疗2型糖尿病伴轻度认知障碍的临床疗效。方法 90例诊断为2型糖尿病伴轻度认知障碍患者随机分成对照组和治疗组,治疗组在对照组基础上给予丁苯酞胶囊治疗,6个月后比较两组蒙特利尔认知评估(Mo CA)评分和及事件相关电位P300,并观察药物不良反应。结果与对照组相比,治疗组Mo CA量表评分提高(P<0.01),P300潜伏期缩短、波幅增高(P<0.05),且未发现明显不良反应。结论丁苯酞胶囊能提高2型糖尿病伴轻度认知障碍患者的认知功能,值得临床上进一步推广和应用。Objective To discuss the effect of butylphthalide soft capsules in the treatment of type 2 diabetic patients with mild cog-nitive impairment.Methods Ninety cases of diagnosed type 2 diabetic with mild cognitive impairment were randomly divided into two groups：the treatment group （n=45） and the control group （n=45） .Patients in both groups were treated with the traditional therapy, but those in the study treatment group were given butylphthalide soft capsules.MoCA and P300 were used as the effect judge standard after June.Results Compared with the control group, the MoCA score was increased in the treatment group（P〈0.01）, P300 latency was shorten and P300 amplitude was increased （P〈0.05）.Conclusion Butylphthalide capsules can improve cognitive function in patients with type 2 diabetes patients with mild cognitive impairment, and worthy of further clinical promotion and application.

关 键 词：2型糖尿病 轻度认知障碍 丁苯酞 

分 类 号：R587[医药卫生—内分泌]