狂犬病疫苗2-1-1方案的初种与复种效果的动态观察  

Dynamic Observation on First-immunization and Re-immunization Effects of Rabies Vaccine 2-1-1 Regimen

作　　者：蒋学友[1] 张建[1] 郑以山[1] 王念跃[1] 仲崇辉[1] 

机构地区：[1]东南大学第二附属医院急诊科,南京210003

出　　处：《医学研究杂志》2015年第7期80-83,共4页Journal of Medical Research

基　　金：江苏省卫生厅科研基金资助项目(Y2012075)

摘　　要：目的观察狂犬病疫苗2-1-1接种方案的初种与复种免疫效果。方法根据3年以前有无狂犬病疫苗接种史分两组进行实验研究:A组:无既往狂犬病疫苗接种史的2-1-1方案初种组;B组:有既往史的2-1-1方案复种组。观察指标包括狂犬病疫苗抗体效价和阳性率。结果复种组人群在7、21天时狂犬病疫苗抗体效价和阳性率方面均高于初种组,差异有统计学意义。45天时两组间狂犬病疫苗抗体效价有统计学差异,但是阳性率差异无统计学意义。结论狂犬病疫苗复种组的免疫效果明显优于初种组,复种者早期(7天)即可出现有效浓度的抗狂犬病抗体,因此从事狂犬病高暴露风险者接受暴露前免疫是非常必要的。Objective To observe first-immunization and re-immunization effects of rabies vaccine 2-1-1 regimen.Methods According to the the past history of rabies vaccine inoculation before three years,the volunteers were divided into two groups for experimen-tal research：groupA first-immunization of 2-1-1 regimen without past history of rabies vaccine,groupB re-immunization of 2-1-1 regimen with past history of rabies vaccine.The observation indexes included rabies neutralizing antibodies titer and positive rate. Results The rabies neutralizing antibodies titer and positive rate in group B were both statistically higher than those in group A on 7th and 21st day.There was statistical difference in rabies neutralizing antibodies titer, but wasn′t statistical difference in positive rate positive between group A and group B on 45th day.Conclusion The re-immunization effect of rabies was significantly better than the first-im-munization effect.The effective rabies neutralizing antibodies titer occurred earlier on 7th day in Reimmunization,so it was quite neces-sary to receive pre-exposure vaccination for the people engaged in the work with high exposure to rabies risk.

关 键 词：狂犬病疫苗 免疫效果 分析 实验研究 

分 类 号：R535[医药卫生—内科学]