慢性阻塞性肺疾病合并心血管疾病的机制及治疗进展  

Mechanisms and treatment of chronic obstructive pulmonary disease with cardiovascular disease

作　　者：王晓月[1] 黄茂[1] 孙培莉[1] 

机构地区：[1]南京医科大学第一附属医院呼吸内科,210029

出　　处：《国际呼吸杂志》2015年第15期1193-1196,共4页International Journal of Respiration

摘　　要：大量流行病学研究认为COPD与心血管疾病之间有着密切联系。COPD并发心血管疾病的机制复杂多样，除了与系统性炎症反应有关，还可能与氧化应激、交感神经兴奋性增加、血管壁异常、血液高凝状态和血小板活化、衰老速度加快、蛋白酶／抗蛋白酶平衡失调等有关。COPD并发心血管疾病的治疗包括吸氧、运动、口受体激动剂及阻滞剂、抗血小板治疗、他汀类药物、抗氧化应激治疗等。本文就COPD合并心血管疾病的发生机制及其治疗进展作一综述。Numerous epidemiologie studies have dose linked the presence of chronic obstructive pulmonary disease （COPD） to cardiovascular disease. The mechanisms responsible for the increased risk of cardiovascular disease in patients with COPD are complex, not only associated with systemic inflammatory response, but also with oxidative stress, sympathetic overactivity, abnormalities of the vascular wall, blood high condensation state and platelet activation, accelerated aging, protease/ antiprotease imbalance and so on. The treatment of COPD with cardiovascular diseases including oxygen, exercise, beta agonists and blockers, antiplatelet therapy, statins, antioxidant stress treatment, etc. In this paper,COPD merger of cardiovascular disease mechanisms,therapy were reviewed.

关 键 词：慢性阻塞性肺疾病 心血管疾病 机制 治疗 

分 类 号：R543.3[医药卫生—心血管疾病]