正交试验优选苦石莲胶囊乙醇提取工艺  

Optimization of ethanol extraction process for Caesalpinia Minax Capsules by orthogonal test

作　　者：唐炳兰[1] 莫单丹[1] 刘振杰[1] 袁经权[1] 周小雷[1] 缪剑华[1] 

机构地区：[1]广西药用植物研究所天然药物化学组分研究室,广西南宁530001

出　　处：《中国医药导报》2015年第22期33-35,39,共4页China Medical Herald

基　　金：广西壮族自治区卫生厅中医药科技专项项目(GZYZ1112);广西科学研究与技术开发计划项目(桂科转1298009-22);广西壮族自治区南宁市科学研究与技术开发计划项目(201102088C)

摘　　要：目的优选苦石莲胶囊提取工艺。方法采用L9(34)正交试验法,以化合物Neocaesalpin L提取率为指标,考察提取方法、乙醇体积分数、提取时间、提取次数、乙醇用量对Neocaesalpin L提取率的影响。结果最佳提取工艺为用25倍量的95%乙醇,提取2次,每次提取时间1.5 h。结论优选的工艺稳定,可为工业化生产提供依据。Objective To optimize the extraction process of Caesalpinia Minax Capsules. Methods The extraction of Caesalpinia Minax Capsules was determined by L9（34） orthogonal test with Neocaesalpin L extraction rate as index, and the effects of extraction method, concentration of alcohol, extraction times and frequency and the amount of ethanol added on Neocaesalpin L extraction rate were investigated. Results The optimal extraction condition was 25 folds amount of 95% ethanol, 2 times, 1.5 h each time. Conclusion The optimized process is stable, which can offer evidence for industrial production.

关 键 词：苦石莲胶囊 正交试验 提取工艺 Neocaesalpin L 

分 类 号：R943.1[医药卫生—药剂学]