烟酰胺腺嘌呤二核苷酸磷酸氧化酶对血管疾病病理过程的影响  

Influence of NADPH oxidases on vascular disease pathological process

作　　者：孙涛[1] 杨蒙蒙[1] 朱宝义[2] 张琰[1] 

机构地区：[1]第四军医大学唐都医院药学部,陕西西安710038 [2]第四军医大学唐都医院眼科,陕西西安710038

出　　处：《中国医药导报》2015年第22期43-46,54,共5页China Medical Herald

基　　金：陕西省科技计划社会发展公关项目(2012SF2-02-2)

摘　　要：氧化应激是一种活性氧(ROS)代谢引起的分子失调,以一氧化氮生物利用度下降为特征。使用抗氧化维生素E和维生素C对心血管疾病无明显疗效,这使得对氧化应激的分子本质的理解产生了变化。氧化应激不再被认为是产生和消除ROS之间的不平衡,而是酶功能的异常,特别是烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶功能的异常。因此,NADPH氧化酶已成为重要的治疗靶点。为了设计正确的抗氧化治疗方案,必须考虑NADPH氧化酶的分子调节作用,以及新型该家族人类同源物Nox1、Nox2、Nox3、Nox4和Nox5。通过发展和评估可靠的局部和系统抗氧化应激技术抑制NADPH氧化酶,可能比使用抗氧化剂非选择性消除所有ROS更加有效。Oxidative stress is a molecular dysregulation in reactive oxygen species（ROS） metabolism, which is characterized by a loss of nitric oxide bioavailability. It is shown there is no clinical benefit of antioxidant vitamin C or vitamin E treatment for vascular disease, which has changed the understanding of the molecular nature of oxidative stress. Oxidative stress is no longer perceived as a simple imbalance between the production and scavenging of ROS,but as a dysfunction of enzymes involved in ROS production, especially the dysfunction of NADPH oxidases. Thus NADPH oxidases are important therapeutic targets. In order to properly design trials of antioxidant therapies, molecular aspects of NADPH oxidase regulation must be considered, while thinking about novel pharmacological targeting of this family of enzymes consisting of several homologs Nox1, Nox2, Nox3, Nox4 and Nox5 in humans. The development of reliable techniques for the assessment of local and systemic oxidative stress may be potentially much more efficient than non-selective scavenging of all ROS by the administration of antioxidant.

关 键 词：活性氧 NADPH氧化酶 血管疾病 分子机制 

分 类 号：R544.1[医药卫生—心血管疾病]