声脉冲辐射力成像对正常胎盘及重度子痫前期患者胎盘功能的初步研究  

Preliminary study of acoustic radiation force impulse in the placental function of normal population and patients with severe preeclampsia

作　　者：袁鹰[1] 刘华[2] 李胜利[1] 文华轩[1] 郑美玉[1] 陈琮瑛[1] 毕静茹[1] 郑琼[1] 余蓉[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院超声科,深圳518028 [2]深圳市南山区妇幼保健院儿科

出　　处：《中华超声影像学杂志》2015年第7期601-605,共5页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金面上项目（81270707）;国家自然科学基金青年基金项目（61101026）;2011年深圳市重点科技计划项目（201101013）;2011年深圳市科技计划项目（201103203）

摘　　要：目的探讨声脉冲辐射力成像（acousticradiationforcsimpulse，ARFI）技术定量分析胎盘弹性的临床应用价值。方法正常妊娠孕妇487例，测量胎盘组织剪切波速度（shearwavevelocity，SWV）。根据不同孕周、胎盘位置及感兴趣区域取样深度分组，采用单因素方差分析，比较正常胎盘不同位置及感兴趣区域不同取样深度之间swV的差异。采用Pearson相关分析评估正常胎盘SwV与不同孕周及胎盘分级之间的可能关系。重度子痫前期孕妇26例，重度子痫前期合并胎儿生长受限（fetalgrowthrestriction，FGR）孕妇25例，分别测量胎盘SWV，与正常胎盘SwV比较。取50例正常胎盘与异常组51例胎盘行病理检测。结果根据胎盘位置分前壁、侧壁及后壁3组。单因素方差分析显示，前壁或侧壁与后壁swv比较差异有统计学意义（P〈0．05），前壁与侧壁SWV比较差异无统计学意义。根据感兴趣区域取样深度不同，将取样深度距离探头（范围2．O～7．99cm）每增加1cm为1组，共分成6组。距离探头范围2．0～5．99cm与6．0～7．99cm之间的两组SWV比较差异有统计学意义（P〈0．05），其余各组swV比较差异无统计学意义。正常胎盘组织swV均值为（0．78±0．08）m／s，与孕周无相关性，与胎盘分级呈正相关（P〈0．05）。正常组与异常组SwV比较差异有统计学意义（P〈0．05）。重度子痫前期组与重度子痫前期合并FGR组swV比较差异无统计学意义（P〉0．05）。病理检查显示异常组胎盘有显著改变。结论ARFI可便捷、无创地定量分析胎盘实质的弹性程度，并可有效区别正常与异常胎盘组织弹性差异。Objective To investigate the clinical value of acoustic radiation forcs impulse （ARFI） in quantitative evaluating placental elasticity. Methods The study population included 487 normal pregnant women,and ARFI generated shear wave velocity （SWV） was measured. On the basis of gestational ages, placental sites and sampling depths in region of interest （ROI）, the normal population was divided into different groups. One-way analysis of variance was used to compare the discrepancy on the SWV values amomg the nomal placental sites or the sampling depths in ROI. Pearson correlation coefficient were used to assess the possible relationships between the normal placental SWV values and the different gestational ages or the placental grades. A total of 51 cases were diagnosed with severe preeclampsia,among them 25 cases were categorized as severe preeclampsia with fetal growth restriction （FGR）. The placental SWV values were measured and compared with those of the normal population. The pathological examinations were performed on 50 normal and 51 abnormal placentas. Results Basing on the placental sites, the normal population were divided into three groups：anterior wall, lateral wall and posterior wall groups. Compared with the posterior wall group, the placental SWV values in the anterior wall or lateral wall group significantly decreased （ P 〈0.05）. No statistical significant difference was found between the anterior wall group and the lateral wall group. Basing on the distance from the sampling depths to the probe （range from 2 to 7.99 cm,and each additional 1 cm corresponding a group）,the normal population were divided into six groups. There was statistical significant difference for the placental SWV values between the two groups of distance in the range of 2.0 to 5.99 cm and 6.0 to 7.99 cm （ P 〈0.05）. There was no statistical significant difference between the other two groups. The mean SWV value was （0.78 ± 0.（18 m/s） in the normal group. No significant relationships were found

关 键 词：超声检查 产前 胎盘 重度子痫前期 声脉冲辐射力成像 

分 类 号：R714.244[医药卫生—妇产科学]