成人乙肝疫苗不同免疫程序效果观察  

An observation on the immune effect of hepatitis B vaccine by different immunization schedules among adults

作　　者：郭敏建 姚军[2] 李静[3] 

机构地区：[1]桐乡市疾病预防控制中心,浙江桐乡314500 [2]浙江省疾病预防控制中心 [3]宁波大学医学院

出　　处：《浙江预防医学》2015年第8期757-760,共4页Zhejiang Journal of Preventive Medicine

基　　金：艾滋病和病毒性肝炎等重大传染病防治(2009ZX10004-901)

摘　　要：目的：评价成人按不同程序接种乙肝疫苗的免疫效果，为制定成人乙肝免疫策略提供支持。方法按照自愿原则选择桐乡市 HBsAg 和抗－HBs 均阴性16～49岁人群，分别按0－1－3、0－1－6免疫程序接种国产和进口两种10μg 乙肝疫苗，全程免疫后1个月和1年定量检测抗－HBs，对？用10μg国产乙肝疫苗 A 组（0－1－3程序）、B 组（0－1－6程序），10μg 进口乙肝疫苗 C 组（0－1－3程序）、D 组（0－1－6程序）接种后的抗－HBs 阳转率、抗－HBs 几何平均滴度（GMT）水平进行评价。结果完成全程免疫并采集双份免后血样共848人，免疫1个月后抗－HBs 阳转率为99.76％，A 组与 C 组、B 组与 D 组、A 组与 B 组、C 组与 D 组免后抗－HBs 阳转率差异均无统计学意义（P ＞0.05）；A 组的抗－HBs GMT 低于 C 组和 B 组（P ＜0.05），B 组与 D 组抗－HBs GMT 差异无统计学意义（P ＞0.05）；低年龄组抗－HBs GMT 比高年龄组高。免疫1年后抗－HBs 阳转率为70.28％，抗－HBs 阳性率和抗－HBs GMT 均较免后1个月降低。结论成人采用国产10μg 乙肝疫苗按0－1－6免疫程序接种的免疫效果较好。Objective To evaluate the immune effect of hepatitis B vaccine by different immunization schedules among adults,and to provide evidence for developing immunization strategy.Methods Adults aged 1 6 to 49 years with negative HBsAg and anti -HBs in Tongxiang city voluntarily received domestic or imported hepatitis B vaccine.These subjects were divided into 4 groups （Group A：1 0 μg domestic vaccine,0 -1 -3 schedule;group B：1 0 μg domestic vaccine,0 -1 -6 schedule;group C：1 0 μg imported vaccine,0 -1 -3 schedule;group D：1 0 μg imported vaccine,0 -1 -6 schedule）. Quantitative detection of anti -HBs was conducted in 1 month and 1 year,and the anti -HBs positive rate and geometric mean titers of anti -HBs （GMT）were evaluated.Results A total of 848 subjects were evaluated.The anti -HBs positive rate was 99.76% after immunization in 1 month,and no significant differences were observed among different groups （P〉0.05）.The GMT of anti -HBs in group A was significantly lower than that of group C and B （P 〈0.05）,while no significant differences were observed among group B and D.The GMT of anti -HBs was significantly decreased with ages. The anti -HBs positive rate was 70.28% after immunization in 1 year,which was significantly lower than that in 1 month after immunization.Conclusion Better immune effect could be achieved by 1 0 μg domestic hepatitis B vaccine with 0 -1-3 schedule.

关 键 词：成人 乙肝疫苗 免疫 免疫效果 

分 类 号：R186[医药卫生—流行病学]