核素骨显像预测^(99)Tc-MDP治疗类风湿关节炎效果的价值  

Value of nuclide bone imaging forecasting the effect of ^(99)Tc-MDP treating rheumatoid arthritis

作　　者：高利霞[1] 刘鹏[1] 钟彩玲[1] 陈艳[1] 夏天[1] 何国荣[1] 

机构地区：[1]广东省湛江中心人民医院血液风湿科,广东湛江524037

出　　处：《中国当代医药》2015年第21期54-56,共3页China Modern Medicine

基　　金：广东省湛江市第四批非资助科技攻关计划项目(2012C3104047)

摘　　要：目的探讨核素骨显像预测99Tc-MDP治疗类风湿关节炎效果的临床价值。方法 2012年6月~2014年10月,选取诊断明确的39例活动性类风湿关节炎患者在99Tc-MDP治疗前采用放射性核素骨骼显像剂(99m Tc-MDP)对病变关节进行显像,利用感兴趣区(ROI)技术计算病变关节摄取比值(T/N)。99Tc-MDP治疗前及治疗后6周记录患者的关节压痛数、关节肿胀数、晨僵时间,红细胞沉降率(ESR)、C反应蛋白(CRP),将患者分为显效组、有效组及无效组,比较3组的T/N值,同时按T/N值分为高摄取、低摄取组,并进行疗效比较。结果不同疗效组的T/N值差异有统计学意义(P<0.05),显效组的T/N值最高,无效组的T/N值最低。高摄取、低摄取组的疗效差异有统计学意义,高摄取组的疗效优于低摄取组(P<0.05)。结论核素骨显像在预测99Tc-MDP治疗类风湿关节炎效果方面有较高的临床价值,对临床医师优化治疗方案有很好的指导作用。Objective To explore the clinical value of nuclide bone imaging forecasting the effect of ^99Tc-MDP treating rheumatoid arthritis. Methods From June 2012 to October 2014,39 patients with active rheumatoid arthritis diagnosed clearly were taken images for affected joints by radionuclide bone imaging agent （^99mTc-MDP） before ^99Tc-MDP treatment.The uptake ratio （T/N） of affected joints was calculated by region of interest （ROI） technique.Before ^99Tc-MDP treatment and after 6-week therapy,joint tenderness number,joint swelling number,time of morning stiffness,erythrocyte sedimentation rate （ESR）,and C-reactive protein （CRP） were recorded.They were divided into effective markedly group, effective group and ineffective group.T/N value among three groups was compared.According to T/N value,they were divided into high uptake group and low uptake group,in which the therapeutic effect was compared. Results There was a statistical difference of T/N value in different therapeutic group （P〈0.05）,and T/N value in effective markedly group was highest,and lowest in the ineffective group.There was a statistical difference of curative effect between high uptake group and low uptake group,and the curative effect in high uptake group was better than that of low uptake group （P〈 0.05）. Conclusion Nuclide bone imaging has higher clinical value in forecasting effect of ^99Tc-MDP treating rheumatoid arthritis and has a better guidance role for clinicians optimizing therapeutic regimen.

关 键 词：核素骨显像 ^99TC-MDP 类风湿关节炎 

分 类 号：R593.22[医药卫生—内科学]