藿香正气制剂临床不良反应文献分析  

Literature Analysis of Adverse Reactions Induced by Huoxiang Zhengqi Preparation

作　　者：房志鑫[1] 刘瑞丽[2] 武辉[1] 王建彬[3] 

机构地区：[1]新乡医学院三全学院,河南新乡453003 [2]新乡医学院,河南新乡453003 [3]商丘医学高等专科学校,河南商丘476100

出　　处：《河南中医》2015年第6期1434-1436,共3页Henan Traditional Chinese Medicine

摘　　要：目的:观察藿香正气制剂不良反应(ADR)的临床特点和规律,为其临床合理安全使用提供参考。方法:检索中国知网和万方医学数据库,收集有关藿香正气制剂的ADR病例报告36例,在Excel中,对其病例信息进行统计分析。结果:藿香正气制剂不良反应临床表现呈多样性,其中以皮肤损害最多,共24例,占28.92%;其次为循环系统15例(18.07%),呼吸系统14例(16.87%),其他表现(寒战、发热、双硫仑样反应)14例(16.87%),神经系统8例(9.64%),视觉损害4例(4.82%),消化系统3例(3.61%),内分泌系统1例(1.20%)。结论:皮肤损害是藿香正气制剂最常见的不良反应,其口服液(以乙醇为辅料)、不合理的联合用药、过敏体质等因素是其发生不良反应的主要原因。Objective： To study the clinical characteristics of adverse drug reactions induced by Huoxiang Zhengqi Preparation in order to provide references for rational and safe drug use. Methods： 36 case reports from CNKI and Wan Fang Medical Database were searched and analyzed by statistic method. Results： The manifestations were various including 24 cases of skin lesion（ 28. 92%）,15 cases of circulation system lesion（ 18. 07%）,14 cases of respiratory system lesion（ 16. 87%）,etc. and other manifestions（ chills,fever,disulfiram-like reaction）（ 16. 87%）,8 cases of nervous system（ 9. 64%）,4 cases of visual impairment（ 4. 82%）,3 cases of digestive system,1 case of endocrine system（ 1. 2%）. Conclusion： Skin lesion is the most obvious adverse reaction of Huoxiang Zhengqi Preparation. The major causes are oral liquid（ alcohol as adjuvant material）,irrational combined drug use and allergic constitution.

关 键 词：藿香正气制剂 不良反应 文献分析 

分 类 号：R288[医药卫生—中药学]