2型糖尿病肾病不同分期尿液脂联素变化及相关因素  

Changes of urine adiponectin levels and relevant factors in the population with different stage of diabetic nephropathy

作　　者：瞿文娟[1] 程昌琴[1] 杨若梅[1] 蒋先淑 李志勇[1] 杨刚毅[2] 李伶[3] 

机构地区：[1]重庆医科大学附属永川医院内分泌科,重庆402160 [2]重庆医科大学附属第二医院内分泌科,重庆400010 [3]重庆医科大学检验系临床生化教研室和教育部实验诊断重点实验室,重庆400016

出　　处：《重庆医学》2015年第22期3040-3042,共3页Chongqing medicine

基　　金：国家自然科学基金项目(81070640;30971388)

摘　　要：目的探讨2型糖尿病肾病(DN)不同分期尿脂联素(UAPN)的变化及相关因素。方法选择2013年在重庆医科大学附属永川医院住院的119例2型糖尿病肾病患者为研究对象,根据24h尿蛋白排泄量(UAER)将其分为尿蛋白正常组、微量蛋白尿组和大量蛋白尿组,并选取45例健康体检者作为健康对照组。比较各组UAPN水平的变化情况,同时分析患者UAPN与各参数之间的关系。结果正常蛋白尿组的UAPN明显低于微量蛋白尿组和大量蛋白尿组(P<0.01);微量蛋白尿组的UAPN明显低于大量蛋白尿组(P<0.01),而明显高于健康对照组(P<0.01);大量蛋白尿组的UAPN明显高于健康对照组(P<0.01)。多元线性回归结果显示,高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、UAER均对患者的UAPN产生不同程度的影响。结论 DN患者UAPN水平与2型糖尿病肾病有关,其水平增高与HDL-C、FPG、HbA1c、UAER有关。Objective To investigate urine adiponectin changes and related factors in different stage of type-2 diabetic ne- phropathy. Methods A total of 119 DN patients admitted to the Yongchuan Hospital of Chongqing Medical University in 2013 were selected. The general indices and laboratory examination results were retrospectively analyzed. 119 type-2 diabetic nephropathy patients were divided into normal Proteinuria group, micro-Proteinuria group,macro-Proteinuria group,according to urine albumin excretion rate in 24 hours. 45 health subjects from Physical examination center were enrolled as normal group. The UAER of the three groups were compared and the correlation between each index and UAER was analyzed. Results Urine adiponectin levels in normal Proteinuria group was significantly lower than micro-Proteinuria group（P〈~0.01） and macro-Proteinuria group（P〈0.01）. Urine adiponectin levels in micro-Proteinuria group was significantly lower than macro-Proteinuria group （P〈0.01）and higher than normal group（P〈 0.01）. Urine adiponectin levels in macro-Proteinuria group were significantly higher than normal group （P〈 0.01）. Multiple linear regression analysis showed that HDL-C, FPG, HbA1 c and UAER had effects on the levels of Urine adiponec- tin. Conclusion Urinary adiponectin levels are associated with type 2 diabetic nephropatby,and which was related with HDL-C, FPG, HbAlc and UAER.

关 键 词：糖尿病 2型 糖尿病肾病 脂联素 白蛋白尿 

分 类 号：R587.2[医药卫生—内分泌]