生长抑素对脾切除联合断流术术后患者肝功能的影响  

Effect of somatostatin on liver function in patients after splenectomy combined with devascularization

作　　者：范炜[1] 吴晓春[1] 陈圣开[1] 薛强[2] 

机构地区：[1]重庆市第三人民医院肝胆外科,400014 [2]重庆医科大学附属第二医院肝胆外科,400010

出　　处：《重庆医学》2015年第22期3088-3089,3092,共3页Chongqing medicine

摘　　要：目的研究生长抑素对肝硬化、门静脉高压症患者脾切除联合断流术术后肝功能的影响。方法回顾性分析48例肝硬化、门脉高压并食道静脉曲张患者的临床资料,26例(处理组)行脾切除联合断流术术后使用生长抑素2mg/8h,连续使用72h;另22例(对照组)术后未使用生长抑素,术后观察记录治疗前后血清清蛋白(Alb)、谷丙转氨酶(ALT)、丙草转氨酶(AST)、凝血酶原活动度(PTA)及总胆红素(TBIL)的变化。结果两组患者术后均恢复良好,无死亡病例,处理组Alb较对照组明显增高(P<0.05),ALT、AST分别较对照组明显下降(P<0.05),PTA及TBIL亦得到明显改善(P<0.05)。结论术后联合应用生长抑素不仅能降低门静脉压力,控制出血,亦能明显减轻患者肝损害,促进肝功能恢复。Objective To observe the effect of somatostatin on liver function in patients after splenectomy combined with de- vascularization. Methods The clinical data of 48 patients with liver cirrhosis,portal hypertension and esophageal varices were retro- spectively analyzed,26 cases （somatostatin group） were used somatostatin after splenectomy combined with devascularization, and the other 22 cases （control group） were not used. The changes of serum albumin （A[b）, a[anine aminotransferase （ALT）, aspartate transaminase （AST） ,prothrombin activity （PTA） and total bilirubin （TBIL） was observed. Results All patients recovered well af- ter surgery,and no deaths occurred. However, ALT, AST and TBIL of using somatostatin group were significantly reduced than those of control group（P〈0.05）,Alb and PTA were also improved significantly （P〈0.05）. Conclusion The combination of somatostatin can not only reduce postoperative portal pressure, control of bleeding, but also to be significantly promote recovery of liver function.

关 键 词：生长抑素 脾切除术 高血压 门静脉 肝硬化 肝功能 

分 类 号：R657.34[医药卫生—外科学]