三黄颗粒与素代三黄颗粒对小鼠急性炎症模型的效果比较  

EFFECTS OF SANHUANG GRANULES AND SUDAI-SANHUANG GRANULES ON ACUTE INFLAMMATION MICE MODEL

作　　者：刘沛[1] 马乐[1] 王琼[1] 毛晓霞[1] 苗光新[1] 刘翠哲[1] 

机构地区：[1]河北省中药研究与开发重点实验室/承德医学院中药研究所,河北承德067000

出　　处：《承德医学院学报》2015年第4期286-288,共3页Journal of Chengde Medical University

基　　金：国家自然科学基金项目(81073146;81341143);河北省高等学校科学技术研究青年基金项目(2011133);河北省高校重点学科"中药学"建设项目资助

摘　　要：目的:比较三黄颗粒与素代三黄颗粒对小鼠急性炎症模型的作用。方法:建立醋酸致小鼠毛细血管通透性增高和二甲苯诱导小鼠耳廓肿胀模型,比较三黄颗粒与素代三黄颗粒的抗炎作用。结果:三黄颗粒和素代三黄颗粒均能抑制醋酸致小鼠毛细血管通透性增高和二甲苯致小鼠耳廓肿胀,且素代三黄颗粒的效果优于三黄颗粒。结论:素代三黄颗粒对不同急性炎症模型的作用优于三黄颗粒。Objective： To compare the effects of Sanhuang Granules and Sudai-sanhuang Granules on acute inflammation model in mice. Methods： The anti-inflammatory actions of Sanhuang Granules and Sudai-sanhuang Granules were compared by using acetic acid induced capillary permeability increased mice model and xylene induced mice auricle swelling model. Results： Sudai-sanhuang Granules and Sudai-sanhuang Granules could significantly inhibit capillary permeability increasing induced by acetic acid and auricle swelling induced by xylene in mice; Moreover, the effects of Sudaisanhuang Granules were better than Sanhuang Granules. Conclusions： The anti-inflammatory actions of Sudai-sanhuang Granules on different acute inflammation mice model are better than Sanhuang Granules.

关 键 词：素代三黄颗粒 三黄颗粒 毛细血管通透性模型 耳廓肿胀模型 黄芩苷 黄芩素 

分 类 号：R285[医药卫生—中药学]