芪苇胶囊治疗高血压性早期肾损害临床研究  

Clinical Research of Qiwei Capsule in the Treatment of Hypertensive Renal Damage In Early

作　　者：郭泉滢[1] 唐桂军[1] 李星锐[1] 袁小飞[2] 

机构地区：[1]河南省中医药研究院,河南郑州450004 [2]河南中医学院,河南郑州450046

出　　处：《中医学报》2015年第7期1051-1053,共3页Acta Chinese Medicine

基　　金：国家中医药管理局第五批名医传承继承人计划项目

摘　　要：目的:观察芪苇胶囊治疗高血压性早期肾损害的临床疗效。方法:108例患者随机分为治疗组72例和对照组36例,对照组常规给予血管紧张素转化酶抑制剂或血管紧张素受体阻断剂药物口服;治疗组加用具有益气活血、清利湿热功效的芪苇胶囊口服。治疗前后分别作尿微量白蛋白、β2-微球蛋白检测,观察两组临床疗效、血尿素氮、血肌酐、微量白蛋白、α1-微球蛋白和β2-微球蛋白变化。结果:治疗后,对照组有效率为66.67%,治疗组有效率为95.83%,两组比较差异有统计学意义(P<0.05);两组患者尿微量白蛋白、α1-微球蛋白和β2-微球蛋白指标比较,差异有统计学意义(P<0.05);两组患者血尿素氮、血肌酐比较,差异有统计学意义(P<0.05)。结论:芪苇胶囊治疗高血压性早期肾损害疗效显著。Objective：To observe the clinical curative effect of Qiwei capsule in the treatment of hypertensive renal damage.Methods：1 08 patients were randomly divided into treatment group（72 cases）and control group（36 cases）.The control group was given conventional angiotensin converting enzyme inhibitors or vascular angiotensin receptor blocking agent and treatment group was treated with Qi Wei capsule.Detect the urinary albumin and beta 2 microglobulin before and after treatment.Observe the clinical efficacy of the two groups, blood urea nitrogen,creatinine,albumin,α1 -micro protein and beta 2-microglobulin changes.Results：The effective rate was 66.67% in control group and 95.83% in the treatment group after treatment.The difference between the two groups has statistical significance（P 〈0.05）.Compared the urinary albumin,α1 -micro protein and beta microballoons protein targets of two groups,the difference was statisti-cally significant（P 〈0.05）.Compared the blood urea nitrogen and serum creatinine of two groups,the difference was statistical signifi-cant（P 〈0.05）.Conclusion：The curative effect of Qiwei capsule in the treatment of hypertension with early renal damage is signifi-cant.

关 键 词：芪苇胶囊 高血压性早期肾损害 血管紧张素转化酶抑制剂 血管紧张素受体阻断剂 

分 类 号：R259.441[医药卫生—中西医结合]