生物因子控释技术在软骨修复领域的研究进展  

RESEARCH PROGRESS OF CONTROLLED RELEASING DELIVERY OF BIOLOGICAL FACTORS FOR CARTILAGE REPAIR

作　　者：陈家磊[1] 项舟[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国修复重建外科杂志》2015年第8期1034-1037,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(31370984)~~

摘　　要：目的对近年生物因子控释技术在软骨修复领域的研究进展作一综述。方法广泛查阅近年有关生物因子控释技术在软骨修复领域的国内外文献并进行综述。结果目前有多种生物因子用于软骨修复领域,为达到更佳软骨修复效果,可将其与可降解生物材料支架结合,或通过微粒与纳米粒等多种方式实现控释。同时,研究多种生物因子的控释系统和序贯释放技术也是必然选择。结论尽管目前仍面临许多未解决的问题,软骨修复生物因子的控释技术具有可控性和精细化等特点,已成为关节软骨修复领域研究热点。Objective To summarize the recent progress of the controlled releasing delivery of biological factors for cartilage repair. Methods The recently published 1iterature at home and abroad on the controlled releasing delivery of biological factors for cartilage repair was reviewed and summarized. Results Various biological factors have been applied for repairing cartilage. For better cartilage repair effects, controlled releasing delivery of biological factors can be applied by means of combining biological factors with degradable biomaterials, or by micro- and nano-particles. Meanwhile, multiple biologic delivery and temporally controlled delivery are also inevitable choices. Conclusion Although lots of unsolved problems exist, the controlled releasing delivery of biological factors has been a research focus for cartilage repair because of the controllability and delicacy.

关 键 词：生物因子 控释技术 软骨修复 

分 类 号：R681.3[医药卫生—骨科学]