破骨细胞非溶骨功能研究进展  

RESEARCH PROGRESS OF OSTEOCLASTS FUNCTION BEYOND BONE RESORPTION

作　　者：吴朝锐 张杰[2] 田京[2] 

机构地区：[1]南方医科大学第二临床医学院,广州510280 [2]南方医科大学珠江医院骨科

出　　处：《中国修复重建外科杂志》2015年第8期1038-1042,共5页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的综述破骨细胞除骨吸收之外的功能研究进展。方法查阅近年来与破骨细胞功能研究相关的文献,排除与骨吸收有关的文献,并进行分析总结。结果破骨细胞从骨基质调节因子、双向信号和细胞因子3个方面调节骨形成,参与造血微环境的形成,造血干细胞动员及其数量、功能的维持,以及血管生成过程。结论目前对破骨细胞调节造血作用的确切机制仍缺乏深入了解;此外,破骨细胞耦联因子作用于成骨细胞分化的哪一过程、诱导的血管生成参与哪些生理或病理过程等关键问题也有待解决;揭示其内在机制有助于为治疗多种破骨细胞相关性疾病提供科学的策略。Objective To review the osteoclasts（OC） function beyond bone resorption. Methods The related literature on OC function beyond bone resorption was reviewed, analyzed, and summarized. Results OC control the bone formation through releasing of matrix-derived growth factors, bidirectional cell-to-cell signals, and secreting OC-coupling factors, and play an important role in the niche formation, hematopoietic stem cells mobilization, and maintenance of its quantity and function; besides, OCs also regulate angiogenesis. Conclusion These discoveries greatly enrich the current knowledge of OC function and open up an all-new research domain. However, the exact regulatory mechanism of OC affecting the hematopoiesis is still lack in-depth understood. Additionally, it remains to be elucidated how OC-coupling factors act on osteoblast lineage differentiation and how OC-induced angiogenesis participates in physiological and pathological processes. Unclosing the underlying mechanisms will facilitate providing scientific therapeutic strategies for treatment of many OC-related diseases.

关 键 词：破骨细胞 成骨细胞 造血干细胞 血管生成 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]