杜仲的化学成分及药理作用研究进展  

Chemical constituents and pharmacology of Eucommia ulmoides Oliv.

作　　者：冯晗[1,2] 周宏灏[1,2] 欧阳冬生[1,2] 

机构地区：[1]中南大学湘雅医院临床药理研究所 [2]中南大学临床药理研究所遗传药理学湖南省重点实验室

出　　处：《中国临床药理学与治疗学》2015年第6期713-720,共8页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家科技支撑计划(SQ2010BAJY1411-08);湖南省自然科学基金(14JJ4006);长沙市科技计划项目(K1202039);中南大学研究生自主探索创新项目(2014zzts324)1

摘　　要：杜仲又名木棉、思仙、思仲、思锦树,是第三纪冰川运动遗留下来的古老树种。杜仲的主要资源在中国,是我国二级珍稀保护植物。从杜仲中提取的化学成分按其结构可分为木脂素类、环烯醚萜类、黄酮类、苯丙素类、萜类、多糖类等。杜仲具有降血压、降血脂、降血糖、抗肿瘤、抗菌抗病毒、抗炎、抗氧化、保肝护肾、抗骨质疏松等药理作用。其在中国、韩国、日本等有着悠久的药用历史。本文综述了杜仲的化学成分及药理作用研究进展,为杜仲活性成分的药理研究及开发利用提供理论依据。Eucommia ulmoide also is called Mumian,Sixian,Sizhong,Sijinshu,which is an ancient species left in tertiary glacier movement.The major resource of Eucommia ulmoide is in China,and E. ulmoide is second rare and protected plants in China. The active phytochemicals found in E. ulmoides are divided into lignans,iridoids,flavonoids,phenylpropanoids,terpenoids and polysaccharide. Eucommia ulmoide displays extensive pharmacological action, as anti-hypertension, anti-hyperlipidemia,anti-hyperglycemic,anti-tumor,antibacterial,anti-virus,anti-inflammatory,anti-oxidative,hepatoprotection,renoprotection and anti-osteoporosis. E. ulmoide has long medical history in China,Korea and Japan. This review summarizes the progress in chemistry and pharmacology of E. ulmoides,providing theoretical basis for the pharmacological studies and development of active constituents in E. ulmoides.

关 键 词：杜仲 化学成分 药理作用 

分 类 号：R28[医药卫生—中药学] R96[医药卫生—中医学]