Effect of Heat Treatment on Cu Distribution,Antibacterial Performance and Cytotoxicity of Ti-6Al-4V-5Cu Alloy  

作　　者：Zheng Ma Ling Ren Rui Liu Ke Yang Yu Zhang Zhenhua Liao Weiqiang Liu Min Qi R.D.K.Misra 

机构地区：[1]Institute of Metal Research,Chinese Academy of Sciences [2]School of Materials Science and Engineering,Dalian University of Technology [3]Orthopedic Department.Guangzhou Military General Hospital [4]Institute of Medical Engineering,Shenzhen Research Institute of Qinghua University [5]Department of Metallurgical and Materials Engineering,University of Texas at El Paso

出　　处：《Journal of Materials Science & Technology》2015年第7期723-732,共10页材料科学技术（英文版）

基　　金：financial supports from the National Basic Research Program of China(No.2012CB619101);the National Natural Science Foundation of China(No.81271957);the Basic Research Project of Shenzhen City(No.JCYJ20120616142847342)

摘　　要：A copper-bearing Ti-6Al-4V-5Cu alloy was processed and subjected to different heat treatments to explore the relationship among microstructure, antibacterial performance, and cytocompatibility. Characterization of microstructure revealed that the solution treated alloy consisted of α phase, α＇ phase and β phase, while besides these phases, the aged alloy also contained the precipitations of intermetallic Ti2Cu compound. The solution treated alloy showed better antibacterial performance with increasing the solution temperature. The Cu ions released from Ti-6AI-4V-5Cu alloy could effectively inhibit the formation of bacterial biofilm on the surface of alloy, and do not induce any cytotoxicity. The optimal heat treatment for Ti-6AI-4V-5Cu alloy was solution treated at 930 ℃, at which it could exhibit both promising antibacterial performance and no cvtotoxicity.A copper-bearing Ti-6Al-4V-5Cu alloy was processed and subjected to different heat treatments to explore the relationship among microstructure, antibacterial performance, and cytocompatibility. Characterization of microstructure revealed that the solution treated alloy consisted of α phase, α＇ phase and β phase, while besides these phases, the aged alloy also contained the precipitations of intermetallic Ti2Cu compound. The solution treated alloy showed better antibacterial performance with increasing the solution temperature. The Cu ions released from Ti-6AI-4V-5Cu alloy could effectively inhibit the formation of bacterial biofilm on the surface of alloy, and do not induce any cytotoxicity. The optimal heat treatment for Ti-6AI-4V-5Cu alloy was solution treated at 930 ℃, at which it could exhibit both promising antibacterial performance and no cvtotoxicity.

关 键 词：Ti-6AI-4V-SCuHeat treatmentMicrostructureAntibacterial performanceCytocompatibility 

分 类 号：TG166.5[金属学及工艺—热处理]