Multifunctional MgF_2/Polydopamine Coating on Mg Alloy for Vascular Stent Application  

作　　者：Xiaoli Liu Zhen Zhen Jing Liu Tingfei Xi Yudong Zheng Shaokang Guan Yufeng Zheng Yan Cheng 

机构地区：[1]School of Materials Science and Technology,University of Science and Technology Beijing [2]Center for Biomedical Materials and Tissue Engineering,Academy for Advanced Interdisciplinary Studies,Peking University [3]Shenzhen Research Institute,Peking University [4]Materials Research Center,School of Materials Science and Engineering,Zhengzhou University

出　　处：《Journal of Materials Science & Technology》2015年第7期733-743,共11页材料科学技术（英文版）

基　　金：financial support of the National Basic Research Program of China(Grant No.2012CB619102);Shenzhen Special Funds for Development of Strategic Emerging Industries(Project No.JCYJ20130402172114948)

摘　　要：Mg alloy is of great potential in the application of vascular stent due to its degradation in physical environment and proper mechanical property. However its mechanical integrity does not meet the clinical requirement clue to relatively fast degradation. Besides, in order to accelerate the re- endothelialization of Mg-based stents, it needs surface modification to improve the attachment, growth and adhesion of endothelial cells （ECs）. To solve the main obstacles, an anti-corrosion and quick endothelialization coating was prepared on novel Mg-Zn-Y-Ncl alloy via a simple two-step immersion method in the present study, first in hydrofluoric acid （HF） then in dopamine tris-Hydrochloric acid （tris -HCI） solution. The coating was uniform and thin, which consisted of two layers--the upper was pol- yclopamine （PDA） layer and the lower was MgF2 layer. The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test. Moreover the HF- PDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation. The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle ceils （VSMCs）, which was preferable for re-enclothelialization. The results suggest that HF-PDA-treatecl Mg -Zn-Y-Nd alloy has great potential in the application of vascular stent and the surface coating method is of great aPPlication value in biodegraclable Mg alloy stent clue to its simplicity and effectiveness.Mg alloy is of great potential in the application of vascular stent due to its degradation in physical environment and proper mechanical property. However its mechanical integrity does not meet the clinical requirement clue to relatively fast degradation. Besides, in order to accelerate the re- endothelialization of Mg-based stents, it needs surface modification to improve the attachment, growth and adhesion of endothelial cells （ECs）. To solve the main obstacles, an anti-corrosion and quick endothelialization coating was prepared on novel Mg-Zn-Y-Ncl alloy via a simple two-step immersion method in the present study, first in hydrofluoric acid （HF） then in dopamine tris-Hydrochloric acid （tris -HCI） solution. The coating was uniform and thin, which consisted of two layers--the upper was pol- yclopamine （PDA） layer and the lower was MgF2 layer. The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test. Moreover the HF- PDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation. The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle ceils （VSMCs）, which was preferable for re-enclothelialization. The results suggest that HF-PDA-treatecl Mg -Zn-Y-Nd alloy has great potential in the application of vascular stent and the surface coating method is of great aPPlication value in biodegraclable Mg alloy stent clue to its simplicity and effectiveness.

关 键 词：Mg-Zn-Y-Nd alloyVascular stentHF converted layerPolydopamineCorrosion resistanceRe-endotheliazation 

分 类 号：R318.08[医药卫生—生物医学工程] TG174.4[医药卫生—基础医学]