牙疼舒滴丸的制备及含量测定  

Preparation and quality standard of toothache drop pills

作　　者：刘辉[1] 邓莉[2] 王盟[1] 赵亚鑫[3] 张爱兰[2] 

机构地区：[1]山东省济宁市第一人民医院医务部,272011 [2]山东省济宁市第一人民医院医疗保险部 [3]山东省济宁市第一人民医院药学部

出　　处：《国际中医中药杂志》2015年第8期728-730,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的制备牙疼舒滴丸并建立其质量标准。方法采用滴制法制备牙疼舒滴丸，采用高效液相色谱法测定本制剂中欧前胡素含量。结果制得的滴丸大小均匀、圆整光滑、硬度适中；薄层色谱法可鉴别出欧前胡素的特征斑点；欧前胡素在0．50-520μg/ml范围内线性关系良好，r=0．9998，平均加样回收率范围为98．38％，RSD值为1．05％。结论该制备方法简单，滴丸成形性好，质量可控。Objective To prepare toothache drop pills and establish its quality standard. Methods The drop pills were prepared by a routine method; HPLC was used for the determination of the EU isoimperatorin content. Results The drop pills were well- distributed in size, smooth and glossy in appearance, mild in hardness; TLC can identify isoimperatorin characteristic spots; Determination of the Indigo 0.50-520 μg/ml linear relationship was good, r=0.999 8, the recovery of 98.38%. RSD values were 1.05%. Conclusion The preparation method of toothache drop pills is simple, and the drop pills are well-shaped with controllable quality.

关 键 词：牙疼舒滴丸 正交试验 欧前胡素 高效液相色谱 

分 类 号：R283.6[医药卫生—中药学]