重复经颅磁刺激(rTMS)治疗慢性主观性耳鸣的短期疗效分析  

The Short-term Effect Analysis of Repetitive Transcranial Magnetic Stimulation(rTMS) in Chronic Tinnitus

作　　者：杨海弟[1] 郑亿庆[1] 区永康[1] 黄夏茵[1] 

机构地区：[1]中山大学孙逸仙纪念医院耳鼻咽喉头颈外科,广东510120

出　　处：《中华耳科学杂志》2015年第2期278-281,共4页Chinese Journal of Otology

基　　金：国家自然科学基金(81170921);广东省自然科学基金(S2011010004576)

摘　　要：目的采取1Hz低频重复经颅磁刺激(rTMS)治疗慢性主观性耳鸣并评价其治疗效果。方法对慢性主观性耳鸣患者46例行1Hz低频rTMS连续治疗2周,治疗前后分别行耳鸣残疾量表评分(THI)评分及主观疗效评估。结果rTMS对耳鸣治疗有明显效果,对主观耳鸣症状总体有效率为63.1%,其中失代偿性耳鸣(THI≥40)的有效率明显高于代偿性耳鸣(THI<40)(77%vs 45%;P<0.001),耳鸣患者治疗前后THI为(51.8±23.5 vs 37.0±18.8;t=5.94,p<0.001),VAS为(6.3±2.4 vs 4.9±1.8;t=5.27,p<0.01),治疗前后有统计学差异。失代偿组与代偿组耳鸣rTMS治疗后THI变化存在显著差异,两组差值为19.4±8.5(df=42,T=4.95,P<0.001)。结论rTMS治疗耳鸣有效,可明显降低THI得分,改善耳鸣症状,特别在失代偿性耳鸣效果更明显。Objective Evaluate the therapeutic effect of 1-Hz repetitive transcranial magnetic stimulation （rTMS） on tinnitus. Methods 46 chronic tinnitus patients were treated with repetitive transcranial magnetic stimulation for two weeks and the therapeutic effects were assessed afterward. Results rTMS treatment could improve tinnitus obviously. The overall effective rate is 63.1% in subjective tinnitus, The effective rate is higher in decompensated tinnitus（THI ~〉40） than compensatot-y tinnitus （THI〈40） （77% vs 45%; P〈0.001）, The THI score of tinnitus patients before and after treatment were r 51.8 ±23.5 and 37 ±18.8; espectively 0=5.94, p〈0.001）, VAS were 6.3±2.4 and 4.9 ± 1.8;（t=5.27, p〈0.01.） The difference of the changes of THI between decompensated tinnitus and compensated tinnitus group after rTMS treatment was 19.4 ± 8.5 （df=42, T =4.95, P 〈 0.001）. Conclusions rTMS could improve tinnitus, especially for decompensated tinnitus patients.

关 键 词：重复经颅磁刺激 主观性耳鸣 耳鸣残疾量表 疗效 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]