卡托普利对动脉粥样硬化患者肱动脉内皮依赖性舒张功能的改善作用  

Effects of captopril on brachial artery endothelium-dependent vasodilation in patients with atherosclerosis

作　　者：刘运芳[1] 赵玉霞[2] 张梅[3] 于会明[4] 徐琼[1] 钟宁[1] 尹秀玲[1] 宋文延[1] 

机构地区：[1]山东大学医学院诊断学教研室 [2]山东大学齐鲁医院中医科 [3]山东大学齐鲁医院心内科 [4]山东省医学科学院

出　　处：《山东大学学报（医学版）》2002年第4期322-323,共2页Journal of Shandong University:Health Sciences

基　　金：山东省卫生厅"九五"攻关课题 ( 9711)

摘　　要：目的 :观察卡托普利对动脉粥样硬化(AS)患者血浆一氧化氮 (NO)、内皮素 (ET-1 )水平及内皮依赖性血管舒张功能的影响。方法 :应用高分辨率超声技术检测 5 2例服用和 48例未服用卡托普利的AS患者的肱动脉内皮依赖性舒张功能 ,并测定其血浆NO、ET -1水平。结果 :经卡托普利治疗后AS患者肱动脉内皮依赖性舒张功能得到改善 ,同时血浆ET -1水平降低 ,NO水平升高 ,与对照组比较有统计学差异。结论 :卡托普利能有效改善AS患者的血管内皮依赖性舒张功能 ,并能降低血浆ET -1水平 ,升高NO水平。Objective: To investigate the therapeutic effects of captopril on endothelium dependent vasodilation function and the levels of nitric oxide(NO) and endothelin 1(ET 1) in patients with atherosclerosis. Methods: One hundred subjects with atherosclerosis were randomly divided into test group treated with captopril and control group.The endothelial function of the brachial artery was measured with high resolution ultrasound techniqne, and their levels of plasma NO and ET 1 were also detected. Results: After therapy with captopril for six months, the level of plasma ET 1 was lowered, the NO level was increased and brachial flow mediated dilatations was improved significantly compared with the control group. Conclusion: Captopril may effectively improve the endothelium dependent vascular vasodilation function, raise plasma NO level and reduce plasma ET 1 level.

关 键 词：卡托普利 内皮 血管 一氧化氮 内皮缩血管肽类 超声检查 

分 类 号：R543.5[医药卫生—心血管疾病]