人羊膜上皮细胞及其免疫调节功能  

Human Amniotic Epithelial Cell and Its Immunomodulatory Effects

作　　者：司家文[1] 沈国芳[1] 郭礼和[2] 

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颅颌面科,上海200011 [2]中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海200031

出　　处：《中国细胞生物学学报》2015年第7期1059-1062,共4页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:81371122)资助的课题~~

摘　　要：人羊膜上皮细胞,作为一种处于特殊分化阶段和组织来源的干/祖细胞,不仅可在体内外特定环境下向三个胚层组织分化,还表现出独特的免疫豁免和免疫调节功能,使其在细胞治疗、组织再生领域展现出广阔的研究和应用前景。随着人羊膜上皮细胞免疫调节及其机制研究的深入,其在免疫相关疾病治疗方面的研究和应用价值逐渐突显。在此,笔者就近年来人羊膜上皮细胞细胞生物学特性及其免疫调节功能的研究进展进行综述,以期为相关领域研究的开展提供参考。Human amniotic epithelial cells, a special type of stage and tissue specific stem/progenitor cells, have been shown to possess multi-differentiation potential under certain circumstances in vitro and in vivo, and exhibit unique immune privilege characteristics and immunomodulatory effects, which shows the broad research and application prospects of these cells in cell therapy and tissue regeneration fields. With further research progress on the immunomodulatory role of human amniotic epithelial cells, these cells gradually show the potential research and application value in the treatment of immune related diseases. This review focuses on the research progress in biological characteristics and immunomodulatory effects of human amniotic epithelial cells, which may provide references for other relevant studies.

关 键 词：人羊膜上皮细胞 多能性 免疫调节 细胞治疗 

分 类 号：R392.12[医药卫生—免疫学]