高压氧预处理对模拟海拔4000 m 急性暴露人体最大摄氧量和台阶试验指数的影响  

Effects of hyperbaric oxygen preconditioning on maximal oxygen uptake and walking-up the stairs index of the subjects when exposed to simulated 4 000 m acute hypoxia

作　　者：刘洪涛[1] 李洋洋[1] 张延猛[1] 石路[1] 

机构地区：[1]上海交通大学海洋水下工程科学研究院,上海200233

出　　处：《中华航海医学与高气压医学杂志》2015年第3期173-177,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的：探讨高压氧预处理（ hyperbaric oxygen preconditioning ，HBOP）对急性高海拔暴露人体最大摄氧量（ maximal oxygen uptake ，VO2max ）和台阶试验指数的影响。方法第1天，8名被试者在海平面高度（简称“海平”）连续做登台阶运动5 min，台阶高30 cm，频率25次／min，节拍器控制节奏。测安静状态和恢复期的心率、血氧饱和度（ SaO2）、呼出气末端CO2量，以及运动时心率、SaO2，所测值为海平对照值。第2天，行4000 m急性暴露并做与第1天同样的登台阶运动，所测值为4000 m对照值。第3～9天进行HBOP，1次／d，90 min／次，在第3、5、7次HBOP结束0．5 h后行4000 m急性暴露并做与第1天同样的登台阶运动，试验结束后返回海平。根据心率推算出VO2max和台阶试验指数。结果（1） HBOP第7次试验结束后即刻心率[（158．82±9．08）次／min]，与4000 m对照值[（167．58±7．63）次／min]比较下降明显，差异有统计学意义（P＜0．05）。（2）HBOP第7次试验结束后即刻台阶试验指数（46．41±7．30）与4000 m对照值（45．36±4．70）、HBOP第5次试验结束后即刻（45．66±4．75）比较明显提高，差异有统计学意义（P＜0．05）。（3）HBOP 第7次试验结束后即刻VO2max[（46．41±7．30）ml／（kg· min）]，与4000 m对照值[（42．30±4．59）ml／（kg· min）]比较明显升高，差异有统计学意义（P＜0．05）。（4）安静状态下 SaO2，HBOP 第7次后为（82．25±3．37）％，与4000 m 对照值[（79．00±5．58）％]比较显著升高，差异有统计学意义（P＜0．05）；运动后即刻SaO2，HBOP 第5次[（76．50±4．17）％]、第7次[（76．25±4．60）％]与4000 m对照值比较显著升高，差异有统计学意义（P＜0．05）。结论 HBOP后行急性高海拔暴露，人体VO2max和台阶试验指数增加，运动能力提高。Objective To investigate the effects of hyperbaric oxygen preconditioning （ HBOP ） on maximal oxygen uptake （ VO2max ） and walking-up the stairs index of the subjects with acute high altitude exposure.Methods At day 1, 8 subjects had walking-up the stairs exercise at the sea level for five minutes at a rate of 25 steps per minute , with the height of each step being 30 cm.A pacer was used to control the rate of walking up the stairs .Heart rate （ HR） , arterial oxygen saturation （ SaO2 ） , the amount of end expiratory CO 2 were measured at rest and recovery stage , meanwhile heart rate and levels of SaO 2 at exercise were also detected, with the obtained data being used as the control values at the sea level .At day 2, the subjects were exposed to the simulated 4 000 m high altitude and had the same walking-up the stairs exercise as day 1, with detected data being used as the control values at 4 000 m high altitude.At day 3 to 9, the subjects were exposed to HBO, once a day, 90 minutes per session.Half an hour after completion of HBOP at days 3, 5 and＆nbsp;7, the subjects were exposed to a simulated high altitude of 4 000 m and had the same walking-up the stairs exercise as day 1, and the subjects returned to the sea lever upon completion of the experiment .Maximal oxygen uptake （VO2max） and the walking-up the stairs indexes were calculated by heart rate .Results （1）At the instant after completion of 7th HBOP, the heart rate （158.82 ±9.08） decreased significantly, as compared with that of the control value at 4 000m [（167.58 ±7.63）beats/min], with statistical significance （P 〈0.05）.（2）At the instant after completion of 7th HBOP, the walking-up the stairs exercise values （46.41 ± 7.30）were increased significantly, as compared with those of the control value at 4 000 m（45.36 ±4.70）and the value detected at the instant upon completion of 5th HBOP（45.66 ±4.75）were increased significantly , also with statistical significance （P〈0.05）.（3）At the inst

关 键 词：高压氧 模拟高海拔 台阶运动 最大摄氧量 台阶试验指数 

分 类 号：R339.5[医药卫生—人体生理学]