海勤人员高脂血症患者肠道菌群变化及益生菌治疗的临床研究  

Clinical study on the changes of intestinal flora and probiotic treatment of those afloat navy personnel with hyperlipidemia

作　　者：崔立红[1] 于兰[1] 李超[1] 

机构地区：[1]海军总医院消化内科,北京100048

出　　处：《中华航海医学与高气压医学杂志》2015年第3期211-213,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：海军后勤科研计划课题（CHJ12J026）

摘　　要：目的：探讨高脂血症患者肠道菌群的变化及益生菌在高脂血症治疗中的作用。方法（1）对78例高脂血症患者及78例健康志愿者进行肠道菌群分析。（2）78例高脂血症患者按治疗方法分为2组：他汀治疗组39例、他汀＋益生菌治疗组（联合治疗组）39例，分别于治疗前、治疗后15、30 d检测血清三酰甘油（TG）和胆固醇（TC）水平，于治疗后30 d进行肠道细菌分析。结果（1）高脂血症患者存在肠道菌群失调，主要表现为厌氧菌（嗜酸乳杆菌、双歧杆菌、肠球菌）显著减少，需氧菌（大肠杆菌）增多（P＜0．05）。（2）联合治疗组的TG和TC在治疗后15 d[（1．50±0．30） mmol／L与（5．60±0．88）mmol／L]即有明显下降（P＜0．05），早于他汀治疗组，且肠道菌群失调得到改善。结论高脂血症患者存在肠道菌群失调，提示肠道微生态失衡可能参与了高脂血症的发生发展。益生菌与降脂药物联合应用可快速降低血脂，调整肠道菌群失衡。Objective To investigate the changes of intestinal flora and effects of probiotic treatment on those afloat navy personnel with hyperlipidemia .Methods （1） Analyses of intestinal flora were made in 78 patients with hyperlipidemia and 78 healthy volunteers .（ 2 ） Those patients with hyperlipidemia were randomly divided into 2 groups： the lipitor therapy group and the lipitor ＋probiotic therapy group （ or the combined therapy group ） .Levels of serum trigeminal ganglion （ TG） and total cholesterol （ TC） were detected both before therapy and 15 and 30 days after therapy , and analysis of fecal microbial population was made at day 30 after therapy.Results （ 1 ） There existed imbalance of intestinal flora in patients with hyperlipidemia , with the manifestations of significant decrease in anaerobic bacteria （ Lactobacillus acidophilus , Bifidobacterium , Enterococcus） and obvious increase in aerobic bacteria （E.coli） （P〈0.05）.（2）At day 15, the levels of the serum TG and TC in the combined therapy group [（1.50 ±0.30） mmol/L and（5.60 ±0.88） mmol/L] decreased significantly （P〈0.05）, which was earlier than that of the Lipitor therapy group and the patient ＇s intestinal flora was improved .Conclusions There existed an imbalance of intestinal flora in the patients with hyperlipidemia .Research results indicated that the imbalance of intestinal microecology was probably involved in the occurrence and development of hyperlipidemia .Treatment with probiotics and lipitor could quickly reduce the level of serum TG and TC and help to adjust intestinal flora imbalance .

关 键 词：肠道菌群 高脂血症 益生菌 海勤人员 

分 类 号：R83[医药卫生—航空、航天与航海医学]