Review on hepatic explant pathology of pediatric intestinal transplant recipients:Is it time for an oil change?  

作　　者：Essam Imseis J Marc Rhoads 

机构地区：[1]Department of Pediatrics,Divisions of Gastroenterology and Hepatology,University of Texas Medical School at Houston,Houston,TX 77030,United States

出　　处：《World Journal of Gastroenterology》2015年第17期5115-5118,共4页世界胃肠病学杂志（英文版）

摘　　要：A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product OmegavenTM.The authors have shown from explant livers of children on chronic parenteral nutrition with OmegavenTM that biochemical improvement in cholestasis does not always reflect improvement in liver histology.These findings support 2 small case series that were previously published.Despite improvement and resolution of hyperbilirubinemia in all six infants,five of six infants had persistent or progressive hepatic fibrosis,while only one infant had regression of fibrosis.The study raises questions of whether there is a window of opportunity for efficacy of this preparation;also,an important question is if this omega-3 fatty acid-rich preparation is superior to newer "blended lipids" containing olive,coconut,soy,and fish oil.A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product OmegavenTM.The authors have shown from explant livers of children on chronic parenteral nutrition with OmegavenTM that biochemical improvement in cholestasis does not always reflect improvement in liver histology.These findings support 2 small case series that were previously published.Despite improvement and resolution of hyperbilirubinemia in all six infants,five of six infants had persistent or progressive hepatic fibrosis,while only one infant had regression of fibrosis.The study raises questions of whether there is a window of opportunity for efficacy of this preparation;also,an important question is if this omega-3 fatty acid-rich preparation is superior to newer 'blended lipids' containing olive,coconut,soy,and fish oil.

关 键 词：INTRALIPID Omegaven PARENTERAL nutrition Short BOWEL syndrome Omega-3 FATTY acid 

分 类 号：R726.5[医药卫生—儿科]