人Sirt6基因启动子区结合蛋白的生物信息学分析  

Bioinformatics Analysis of Transcription Factor Binding Site in the Promoter of Human Sirt6 Gene

作　　者：颜冬菁[1] 王青松[1] 蔡望伟[1] 唐敏[2] 

机构地区：[1]海南医学院理学院生化与分子生物学教研室,海南 海口 571199 [2]海南医学院理学院生物技术专业实验室,海南 海口 571199

出　　处：《生物技术世界》2015年第6期5-6,共2页Biotech World

基　　金：海南省创新引进集成专项科技合作项目(KJHZ2013-16);海南医学院人才引进基金项目(No.2013005)

摘　　要：目的:对人Sirt6基因启动子区结合蛋白进行生物信息学分析。方法:从Gene Bank数据库中获取人Sirt6基因5’调控区,使用在线软件JASPAR对该序列可能存在的转录因子结合位点进行预测。结果:Relative profile score threshold在85%、90%、95%和100%时,该序列存在939、276、70和9个可能的转录因子结合位点,包含Ahr、SPIB、Pdx1、Prrx2、MZF1、Mafb和KLF5等。结论:人Sirt6基因5’调控区存在多种转录因子的结合位点,这些转录因子大多与免疫系统调节、肿瘤发生和代谢调节等有关。Objective: To analysis of transcription factor binding site in the promoter of human Sirt6 gene. Methods: The 5' regulatory region of Sirt6 gene was obtained from Gene Bank database. The transcriptional binding sites of Sirt6 gene were predicted by online software JASPAR. Results: 939, 276, 70 and 9potential transcription factors binding sites were predicted in the 5' regulatory region of Sirt6 gene when the relative profile score higher than 85%, 90%, 95%and 100%, including Ahr, SPIB, Pdx1, Prrx2, MZF1, Mafb, KLF5 and et al. Conclusion: There were?many transcription factor?binding sites of?human Sirt6 gene5' regulatory region, which were associated with regulation of immune system, tumor occurrence and regulation of metabolism.

关 键 词：人Sirt6基因 启动子5’调控区 转录因子结合位点 

分 类 号：Q756[生物学—分子生物学]