基于固体分散技术的阿司匹林肠溶微丸的制备  

作　　者：赖琼[1] 

机构地区：[1]广州市医药职业学校实训中心,广东广州510430

出　　处：《生物技术世界》2015年第6期161-162,共2页Biotech World

摘　　要：目的:制备阿司匹林固体分散体肠溶微丸。方法:以Eudragit L(EL)作为载体,采用固体分散技术制备阿司匹林肠溶微丸。运用X射线衍射法,扫描电镜法等分析方法研究其晶体性质,并考察其体外释放性能。结果:阿司匹林以无定形分散于固体分散体肠溶微丸中,药物体外释放曲线在胃液中符合零级动力学方程,在肠液中符合一级动力学方程。结论:阿司匹林固体分散体肠溶微丸可以较好地在肠道吸收,从而减少对胃部的刺激。Objective: To prepare the aspirin enteric coated solid dispersion pellets.Methods:The pellets were prepared by using solid dispersion technology,with Eudragit L(EL) as carrier. The X-ray diffraction(XRD) and the scanning electron microscope(SEM) were used to analyze crystal properties. And its in vitro release was also investigated. Results: It suggested that aspirin was present in enteric coated solid dispersion as amorphous substance. The curves of cumulative drug release were fitted the zero-order kinetic equation in gastric juice, and the first-order kinetic equation in intestinal juice. Conclusion: The aspirin enteric coated solid dispersion pellets has good absorption in intestine, and thus to reduce stomach stimulation.

关 键 词：固体分散技术 阿司匹林 肠溶微丸 体外释放度 

分 类 号：TQ461[化学工程—制药化工]