注射用灯盏花素不良反应影响因素logistic回归分析  

Logistic regression analysis on influential factors of adverse reactions caused by Breviscapine for Injection

作　　者：李玲 葛泉丽 郭绍梅[3] 姜善玲[4] 李莲华 陶萍 崔明超[7] 

机构地区：[1]烟台市药品不良反应监测中心,山东烟台264000 [2]烟台山医院,山东烟台264000 [3]莱州市人民医院,山东莱州261400 [4]烟台毓璜顶医院,山东烟台264000 [5]烟台业达医院,山东烟台264100 [6]蓬莱市人民医院,山东蓬莱265600 [7]浙江医药高等专科学校,浙江宁波315100

出　　处：《药学研究》2015年第8期494-496,共3页Journal of Pharmaceutical Research

摘　　要：目的探讨临床应用注射用灯盏花素发生不良反应的可疑影响因素,为临床合理用药提供科学的参考依据。方法以整群抽样方法,随机抽取静脉滴注灯盏花素注射液患者2 886例的完整住院病历,采用logistic回归的多因素分析方法,对注射用灯盏花素不良反应的影响因素进行回归分析。结果患者的年龄、过敏史、用药剂量、药物滴速等因素是注射用灯盏花素不良反应的主要影响因素。结论临床使用注射用灯盏花素时,应严格按照注射用灯盏花素说明书用药,加强用药监护,对患者进行用药指导,确保临床用药安全。Objective To provided the scientific evidence for guiding rational drug use,the suspicious factors of adverse drug reactions（ ADR） of Breviscapine for Injection. Methods By cluster sampling,2 886 integrated medical records used Breviscapine for Injection were investigated and the influential factors of ADR of Breviscapine for Injection were analyzed by logistic regression multiplicity. Results Patients’ age,history of allergies,dosage,drug dripping speed were effect of the adverse reactions. Conclusion When using Breviscapine for Injection,we should bestrictly in accordance with the instructions of Breviscapine for Injection,to strengthen the drug monitoring,and to guide to patients,ensure the safety of clinical medication.

关 键 词：注射用灯盏花素 不良反应 影响因素 LOGISTIC回归 

分 类 号：R969.3[医药卫生—药理学]